Abstract
The gamma-aminobutyric acid (GABA) transporters GAT-1, GAT-2, GAT-3, and BGT-1 have been cloned and identified according to their differential amino acid sequences and pharmacologic properties. In contrast to GAT-1, -2, or -3, BGT-1 is capable of utilizing both GABA and betaine as substrates. Betaine has been suggested to be a protective osmolyte in the brain. Because changes in expression of GABA transporters/BGT-1 might result in alterations in levels of GABA/betaine in the extracellular space, with consequent effects on neuronal excitability or osmolarity, the present study was carried out to explore expression of GABA transporters in the rat hippocampus after kainate-induced neuronal injury. A decrease in GAT-1 and GAT-3 immunostaining but no change in GAT-2 staining was observed in the degenerating CA subfields. In contrast, increased BGT-1 immunoreactivity was observed in astrocytes after kainate injection. BGT-1 is a weak transporter of GABA in comparison to other GABA transporters and the increased expression of BGT-1 in astrocytes might be a protective mechanism against increased osmotic stress known to occur after excitotoxic injury. On the other hand, excessive or prolonged BGT-1 expression might be a factor contribu...Continue Reading
References
Feb 16, 1978·Nature·J V NadlerC W Cotman
Dec 1, 1989·The American Journal of Physiology·M M Cloutier
Mar 28, 1986·Neuroscience Letters·J W OlneyJ Labruyere
Mar 1, 1995·Journal of Neurochemistry·L A BordenR L Weinshank
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·M TakenakaJ S Handler
Sep 1, 1993·Neuron·D AttwellM Szatkowski
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S UchidaJ S Handler
Apr 1, 1993·The Journal of Clinical Investigation·S UchidaJ S Handler
Apr 15, 1996·The Journal of Comparative Neurology·C E RibakN C Brecha
May 1, 1996·Experimental Brain Research·W Y OngA W Liang
Feb 1, 1996·The American Journal of Physiology·J D FerrarisA García-Pérez
Oct 2, 1996·Biochimica Et Biophysica Acta·C E BurnhamJ C Bucuvalas
Aug 1, 1996·Biochemical Society Transactions·H M Kwon
Nov 11, 1996·The Journal of Comparative Neurology·J JohnsonN C Brecha
Oct 1, 1996·Neurochemistry International·L A Borden
Jan 6, 1999·Experimental Neurology·M J HasbaniM P Goldberg
Feb 20, 1999·Neurology·G W MathernP D Adelson
Jan 20, 2000·Journal of Neurocytology·W Y OngL J Garey
May 18, 2000·Brain Research. Molecular Brain Research·M Bitoun, M Tappaz
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S C GrantS J Blackband
Jul 27, 2000·Current Medicinal Chemistry·W Soudijn, I van Wijngaarden
Sep 29, 2000·Glia·M Bitoun, M Tappaz
Nov 14, 2000·Neuroscience·S Al-Noori, J W Swann
Mar 13, 2001·Nephron·J S Handler, H M Kwon
Apr 27, 2001·Pain·C H Ng, W Y Ong
Jul 12, 2002·Journal of Neuroscience Research·M-E Ruiz-TachiquínA Ortega
Citations
Feb 16, 2016·Glia·Anne AlbrechtOliver Stork
Apr 5, 2011·Epilepsy Research·A C LehreN C Danbolt
Sep 8, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mónica E Ureña-GuerreroCarlos Beas-Zárate
Feb 12, 2008·Epilepsy Research·Misty D SmithH Steve White
Jan 12, 2011·Journal of Neurochemistry·Nicole M RowleyH Steve White
Dec 18, 2014·Hippocampus·Shuxi LiuNicholas Gaiano
Nov 8, 2011·Journal of Neuroinflammation·Masaya MiwaMasayuki Hiramatsu
May 6, 2014·Frontiers in Physiology·Stephen A KempsonNiels C Danbolt
Jun 11, 2016·Progress in Neurobiology·Michele CurcioCarlos B Duarte
Apr 2, 2013·Sleep Medicine Reviews·Diane C Lim, Allan I Pack
Apr 8, 2017·Neuroscience·Tessa E FuhrerAndrea Kwakowsky
Aug 22, 2017·International Journal of Molecular Sciences·Karan GovindpaniAndrea Kwakowsky
Sep 18, 2017·Neurochemical Research·Leena S KnightPaul H Yancey
Nov 18, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maria Ek LieAndrew N Clarkson
Jul 1, 2005·Journal of Neurophysiology·Sotirios Keros, John J Hablitz
Sep 28, 2005·Neurochemical Research·Mads OlsenArne Schousboe
Oct 30, 2008·Physiological Genomics·Stian EllefsenGöran E Nilsson
Apr 6, 2020·Neurochemical Research·Maria E K LiePetrine Wellendorph
Nov 11, 2011·American Journal of Physiology. Renal Physiology·Y ZhouN C Danbolt
Dec 23, 2015·Journal of Genetics·Jingyun LiYing Liu
Nov 22, 2020·International Journal of Molecular Sciences·Karan GovindpaniAndrea Kwakowsky
May 4, 2020·International Journal of Biological Macromolecules·Kamil ŁątkaMarek Bajda
May 25, 2021·Brain : a Journal of Neurology·Felicia MermerJing-Qiong Kang
Nov 14, 2017·ACS Chemical Neuroscience·Anas Al-KhawajaPetrine Wellendorph
Sep 23, 2021·ACS Chemical Neuroscience·Dipak D PukaleNic D Leipzig