Changes in galanin immunoreactivity in rat lumbosacral spinal cord and dorsal root ganglia after spinal cord injury

The Journal of Comparative Neurology
K ZvarovaMargaret A Vizzard

Abstract

Alterations in the expression of the neuropeptide galanin were examined in micturition reflex pathways 6 weeks after complete spinal cord transection (T8). In control animals, galanin expression was present in specific regions of the gray matter in the rostral lumbar and caudal lumbosacral spinal cord, including: (1) the dorsal commissure; (2) the superficial dorsal horn; (3) the regions of the intermediolateral cell column (L1-L2) and the sacral parasympathetic nucleus (L6-S1); and (4) the lateral collateral pathway in lumbosacral spinal segments. Densitometry analysis demonstrated significant increases (P < or = 0.001) in galanin immunoreactivity (IR) in these regions of the S1 spinal cord after spinal cord injury (SCI). Changes in galanin-IR were not observed at the L4-L6 segments except for an increase in galanin-IR in the dorsal commissure in the L4 segment. In contrast, decreases in galanin-IR were observed in the L1 segment. The number of galanin-IR cells increased (P < or = 0.001) in the L1 and S1 dorsal root ganglia (DRG) after SCI. In all DRG examined (L1, L2, L6, and S1), the percentage of bladder afferent cells expressing galanin-IR significantly increased (4-19-fold) after chronic SCI. In contrast, galanin expressi...Continue Reading

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Citations

May 8, 2010·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
May 16, 2012·Journal of Molecular Neuroscience : MN·Beatrice M GirardRodney L Parsons
Jun 11, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Simon StudenyMargaret A Vizzard
Dec 3, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen M BraasMargaret A Vizzard
Oct 24, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xiaoyang ZhangPaul C Dolber
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Dec 22, 2004·The Journal of Comparative Neurology·Li-Ya Qiao, Margaret A Vizzard

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