Changes in gene expression as one of the key mechanisms involved in radiation-induced bystander effect

Biomedical Reports
Mykyta Sokolov, Ronald Neumann

Abstract

The radiation-induced bystander effect (RIBE) refers to the manifestation of responses by non-targeted/non-hit cells or tissues situated in proximity to cells and tissues directly exposed to ionizing radiation (IR). The RIBE is elicited by agents and factors released by IR-hit cells. The growing body of data suggests that the underlying mechanisms of the RIBE are multifaceted depending both on the biological (characteristics of directly IR-exposed cells, bystander cells, intercellular milieu) and the physical (dose, rate and type of IR, time after exposure) factors/parameters. Although the exact identity of bystander signal(s) is yet to be identified, the published data indicate changes in gene expression for multiple types of RNA (mRNA, microRNA, mitochondrial RNA, long non-coding RNA, small nucleolar RNA) as being one of the major responses of cells and tissues in the context of the RIBE. Gene expression profiles demonstrate a high degree of variability between distinct bystander cell and tissue types. These alterations could independently, or in a signaling cascade, result in the manifestation of readily observable endpoints, including changes in viability and genomic instability. Here, the relevant publications on the gene ...Continue Reading

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Citations

Feb 23, 2019·Nihon Hoshasen Gijutsu Gakkai zasshi·Kazumasa Minami
Sep 20, 2020·International Journal of Molecular Sciences·Tatiana V RozhkoNadezhda S Kudryasheva
Jun 15, 2021·Frontiers in Endocrinology·Liu XiaoLin Li
Dec 3, 2021·International Journal of Radiation Biology·Neha Verma, Ashu Bhan Tiku

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Methods Mentioned

BETA
chromosomal aberrations
electrophoretic mobility shift
X-ray

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