PMID: 8594207Oct 1, 1995Paper

Changes in gene expression following traumatic brain injury in the rat

Journal of Neurotrauma
R L HayesT K McIntosh

Abstract

This paper reviews changes in gene expression produced by two rodent models of traumatic brain injury: cortical impact injury and fluid-percussion injury. Cortical impact injury produces transient increases in c-fos mRNA expression, which begin as early as 5 min after injury and subsides by 1 day after injury in the cerebral cortex ipsilateral to injury. In addition, AP-1 transcription factor binding is greatly increased in the injured cerebral cortex at 1, 3, and 5 h post-injury. AP-1 binding remains increased for at least 1 day after injury, while SP-1 transcription factor binding activity does not increase. Additional studies have confirmed increases in c-fos mRNA expression in the hippocampus at 30 min, 1 h, and 3 h after injury. These increases in c-fos mRNA in the hippocampus preceded increased levels of NGF mRNA that were detected at 1 and 3 h but not at 30 min following injury. Following fluid-percussion injury, increases in c-fos mRNA can be detected as early as 2 h following injury in the cortex ipsilateral to the site of injury as well as in the hippocampus. Heat-shock protein (hsp72) mRNA is also increased in the ipsilateral cortex and hippocampus following fluid percussion injury. By 24 h post-injury, both c-fos an...Continue Reading

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Citations

Sep 13, 2002·Brain Research. Molecular Brain Research·Nobuhide KoboriPramod Dash
Sep 5, 2002·Hearing Research·Robert H HelfertLarry F Hughes
Aug 21, 2004·Journal of Neurotrauma·Joanna Szmydynger-ChodobskaAdam Chodobski
Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
Apr 19, 2007·Journal of Neurotrauma·Jessie S TruettnerW Dalton Dietrich
Sep 8, 2011·Journal of Neurotrauma·Marcela A AvilaDouglas S DeWitt
Jul 21, 2011·Journal of Neurotrauma·Gail D AndersonMichael R Hoane
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