Changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats

Pharmacology, Biochemistry, and Behavior
W J McBrideRichard L Bell

Abstract

The objective of this study was to determine changes in gene expression within the extended amygdala following binge-like alcohol drinking by male adolescent alcohol-preferring (P) rats. Starting at 28 days of age, P rats were given concurrent access to 15 and 30% ethanol for 3 one-h sessions/day for 5 consecutive days/week for 3 weeks. Rats were killed by decapitation 3 h after the first ethanol access session on the 15th day of drinking. RNA was prepared from micropunch samples of the nucleus accumbens shell (Acb-sh) and central nucleus of the amygdala (CeA). Ethanol intakes were 2.5-3.0 g/kg/session. There were 154 and 182 unique named genes that significantly differed (FDR=0.2) between the water and ethanol group in the Acb-sh and CeA, respectively. Gene Ontology (GO) analyses indicated that adolescent binge drinking produced changes in biological processes involved with cell proliferation and regulation of cellular structure in the Acb-sh, and in neuron projection and positive regulation of cellular organization in the CeA. Ingenuity Pathway Analysis indicated that, in the Acb-sh, there were several major intracellular signaling pathways (e.g., cAMP-mediated and protein kinase A signaling pathways) altered by adolescent dr...Continue Reading

References

Oct 1, 1996·Alcoholism, Clinical and Experimental Research·A J RobertsG F Koob
Mar 26, 1998·Alcoholism, Clinical and Experimental Research·G F KoobF Weiss
May 29, 1999·Critical Reviews in Neurobiology·W J McBride, T K Li
Jul 23, 1999·Annals of the New York Academy of Sciences·G E Meredith
Jul 23, 1999·Annals of the New York Academy of Sciences·M D CassellC Shi
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·William J McBride
Dec 19, 2003·Nucleic Acids Research·M A HarrisUNKNOWN Gene Ontology Consortium
Mar 9, 2004·Neurochemical Research·Julie A Treadwell, Shiva M Singh
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Jan 22, 2005·Genes, Brain, and Behavior·H J EdenbergW J McBride
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robnet T KernsMichael F Miles
Nov 4, 2005·The Biochemical Journal·Gwen Lomberk, Raul Urrutia
Feb 2, 2006·BMC Bioinformatics·Jeanette N McClintick, Howard J Edenberg
Apr 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Megan K MulliganSusan E Bergeson
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Bin Zhang, Steve Horvath
Jun 2, 2006·Alcoholism, Clinical and Experimental Research·Vivian B Faden
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D CahoyBen A Barres
Apr 15, 2008·Pharmacology, Biochemistry, and Behavior·Zachary A RoddWilliam J McBride
Jul 26, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·George F Koob, Michel Le Moal
Sep 9, 2008·The International Journal of Biochemistry & Cell Biology·Chih-Chiun Chen, Lester F Lau
Oct 3, 2008·Alcoholism, Clinical and Experimental Research·Leah WetherillTatiana Foroud
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Apr 7, 2009·FEBS Letters·Lucia BanciKostas Tokatlidis
Apr 15, 2009·Molecular and Cellular Biology·Vladislava JuricLester F Lau
Aug 12, 2009·Pharmacology, Biochemistry, and Behavior·Richard L BellWilliam J McBride
Sep 8, 2009·Trends in Endocrinology and Metabolism : TEM·Marta Artal-Sanz, Nektarios Tavernarakis
Sep 24, 2009·Nature Reviews. Molecular Cell Biology·Nobutaka HirokawaShinsuke Niwa
Oct 31, 2009·BMC Biology·Boris TabakoffUNKNOWN WHO/ISBRA Study on State and Trait Markers of Alcoholism
Jun 3, 2010·Frontiers in Bioscience (Scholar Edition)·Qing-Wu YangJing-Cheng Li
Jun 24, 2010·Journal of Psychiatry & Neuroscience : JPN·Sigrun HopeOle A Andreassen
Oct 12, 2010·Seminars in Cell & Developmental Biology·Pablo Sanchez-Soria, Todd D Camenisch
Nov 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mei LiuPeter W Baas
Jan 13, 2011·Alcoholism, Clinical and Experimental Research·Megan K MulliganIgor Ponomarev
Jun 4, 2011·Molecular and Cellular Neurosciences·Darcie L MooreJeffrey L Goldberg
Aug 10, 2011·Pharmacology, Biochemistry, and Behavior·Richard L BellWilliam J McBride
Oct 25, 2011·International Review of Cell and Molecular Biology·Akira KikuchiShinji Matsumoto

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Citations

Sep 15, 2015·Alcoholism, Clinical and Experimental Research·Jose Antonio López-MorenoElena Giné
Aug 26, 2015·Psychometrika·Can ShaoYing Cheng
Aug 20, 2016·Genes, Brain, and Behavior·D N StephensT Duka
Jun 15, 2017·Alcoholism, Clinical and Experimental Research·Nicholas J JuryAndrew Holmes
Mar 14, 2019·Translational Psychiatry·Kevin P JensenJonathan Covault
Aug 4, 2021·Brain, Behavior, and Immunity·Lindsay R MeredithLara A Ray

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