Changes in glial fibrillary acidic protein immunoreactivity in the rat facial nucleus following various types of nerve lesions

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
R Laskawi, J R Wolff

Abstract

We report about changes on astrocytes in the facial nucleus of the rat following various types of peripheral nerve lesions. Astrocyte-specific glial fibrillary acidic protein (GFAP) was labeled by immunohistochemistry and served as a marker for these changes. Increased GFAP immunoreactivity was found in the facial nucleus on the lesioned side within 2-3 days after axotomy. This change lasted longer (up to 1 year) when axon regeneration was prevented or delayed by placing a metal clip on the proximal nerve stump. Lesion of the trigeminal nerve prior to axotomy reduced the degree of GFAP immunoreactivity. No side differences were observed after botulinum toxin application.

Citations

May 16, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Pei ChenShusheng Gong
Mar 9, 2004·Brain Research. Brain Research Reviews·Linda B Moran, Manuel B Graeber
May 29, 1998·Progress in Neurobiology·H Aldskogius, E N Kozlova
Oct 1, 2013·Cellular and Molecular Neurobiology·Yu EndoHiroyuki Ichikawa
Jul 30, 2011·The Journal of Comparative Neurology·Nichole A MesnardKathryn J Jones
Sep 3, 2014·Journal of Anatomy·G Berdugo-VegaA Pascual-Font
Jul 11, 2009·The Journal of International Medical Research·P ChenS S Gong
May 20, 2020·Frontiers in Molecular Neuroscience·Francisco J AlvarezTimothy C Cope
Oct 17, 2017·Brain, Behavior, and Immunity·D O SetterK J Jones

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.