Changes in glomerular hemodynamic response to angiotensin II after subacute renal denervation in rats

The Journal of Clinical Investigation
B J TuckerR C Blantz

Abstract

We examined the changes in glomerular hemodynamics produced by angiotensin II (AII) in both normal Munich-Wistar rats and rats which were unilaterally renal denervated (measured kidney) 4-6 d prior to the measurement periods. Measurements of glomerular dynamics were performed in a control period after plasma volume expansion and during infusion of 11 ng X 100 g body wt-1 X min-1 of AII. The glomerular hydrostatic pressure gradient increased from 38 +/- 1 to 49 +/- 1 mmHg in denervated rats compared with a lesser response in controls (from 39 +/- 1 to 45 +/- 1 mmHg, P less than 0.05). Single nephron plasma flow decreased from 213 +/- 17 to 87 +/- 4 nl X min-1 X g kidney wt (KW)-1 in denervated kidneys versus a more modest decrease in control kidneys (from 161 +/- 9 to 102 +/- 5 nl X min X gKW-1). These changes were due to a greater increase in both afferent and efferent arteriolar resistance after AII infusion in denervated compared with control kidneys. Glomerular AII receptor maximum binding was 1,196 +/- 267 fmol/mg protein in denervated kidneys compared with 612 +/- 89 fmol/mg protein (P less than 0.01) in controls with no change in receptor affinity. We conclude the subacute unilateral renal denervation results in renal vas...Continue Reading

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Citations

Aug 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R L Chevalier, B A Thornhill
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·A D Baines
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Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rohit RamchandraSimon C Malpas
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Sriram S NarsipurRoland C Blantz
Feb 15, 2001·The Journal of Laboratory and Clinical Medicine·D SchwartzR C Blantz
Feb 14, 1998·Kidney International·R C Blantz

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