PMID: 8614069May 1, 1996Paper

Changes in granulocyte colony-stimulating factor concentration in patients with trauma and sepsis

The Journal of Trauma
H TanakaT Yoshioka

Abstract

To better understand the role of granulocyte colony-stimulating factor (G-CSF) after the inflammatory response. Serum G-CSF concentrations were measured serially in 19 trauma and 15 sepsis patients. Changes in G-CSF concentration were compared with those in the neutrophil ratio, phagocytic and bactericidal activities, and other cytokines. G-CSF concentrations in trauma patients were elevated on day 1, but quickly decreased within 7 days. G-CSF reached its maximum 3 hours after injury, parallel with peaks of interleukin-6 (IL-6) and IL-8, but not of tumor necrosis factor-alpha (TNF-alpha). In sepsis patients, G-CSF as well as TNF-alpha, IL-6, and IL-8 concentrations were markedly elevated at diagnosis and remained high during the course of the illness. These levels decreased significantly in the 11 survivors. Up to 3 days after the trauma, nonsegmented neutrophil ratios were higher than those thereafter. Neutrophil phagocytic and bactericidal activities remained normal during the course of disease in both conditions. These results suggest that G-CSF plays an important role in the maturation and maintenance of function of neutrophils during the inflammatory response to trauma and sepsis.

References

Nov 1, 1992·The Journal of Trauma·M O'ReillyJ C Hebert
Jul 2, 1992·The New England Journal of Medicine·G J Lieschke, A W Burgess
Aug 1, 1992·The British Journal of Surgery·R J BaigrieP J Morris
Aug 1, 1991·Annals of Surgery·H TanakaT Sugimoto
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B I LordT M Dexter
Oct 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G MorstynK Alton
Sep 1, 1973·American Journal of Clinical Pathology·K Eurenius, R O Brouse
Jan 1, 1983·The Journal of Trauma·V PetersonW A Robinson
Jan 1, 1983·World Journal of Surgery·H R ChampionT K Hunt
Nov 15, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·R KiriyamaN Ohsawa

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Citations

Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D R Kuritzkes
Jan 11, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A GerberH U Schulz
May 15, 2002·Critical Care Medicine·Beatriz M Tavares-MurtaFernando Q Cunha
Aug 10, 2002·The Journal of Trauma·Richard GamelliElisabeth Hahn
Dec 8, 2004·The Journal of Trauma·Pierre A PolettiBernadette Mermillod
Aug 27, 2009·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Norifumi HarimotoYoshihiko Maehara
Jun 9, 2006·World Journal of Emergency Surgery : WJES·F HietbrinkLph Leenen
Nov 28, 2002·Biological Chemistry·Lars Hareng, Thomas Hartung
Aug 2, 2002·Expert Opinion on Investigational Drugs·Sergio ZanottiAnand Kumar
Oct 16, 2012·Journal of the American College of Surgeons·Kristin M CookDavid H Livingston
May 25, 2005·Injury·Marius Keel, Otmar Trentz
Oct 13, 2006·The Veterinary Journal·Emilio Fernández-Varón, Lucía Villamayor
Jul 11, 2006·Lancet·K A BrownD F Treacher
Dec 27, 2005·The Journal of Surgical Research·Masayasu IwaseMasao Nagumo
Nov 18, 2005·The Journal of Surgical Research·Rikako SuzukiMasao Nagumo
Apr 4, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·H SuzukiM Koike
Jun 18, 2005·Memórias do Instituto Oswaldo Cruz·Fernando A BozzaHugo C Castro Faria Neto
Jul 24, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rima A Mohammad
Apr 23, 2014·Nature Reviews. Immunology·Markus G Manz, Steffen Boettcher
Apr 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja FuchsIsaiah R Turnbull
Sep 26, 2019·Frontiers in Immunology·Esmaeil MortazIan M Adcock
Jul 7, 2018·Frontiers in Immunology·Benjamin G Chousterman, Marine Arnaud
Jan 29, 2020·Cold Spring Harbor Perspectives in Medicine·Oakley C OlsonEmmanuelle Passegué
Nov 14, 1997·The American Journal of Physiology·S J WigmoreJ A Ross
May 18, 2021·SAGE Open Medicine·Panid BorhanjooLillian Chow

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