PMID: 476772May 1, 1979Paper

Changes in growth kinetics of jejunal epithelium in mice maintained on an elemental diet

Cell and Tissue Kinetics
S Lehnert

Abstract

Changes in the kinetics of the intestinal epithelium were observed in mice maintained on an elemental diet containing hydrolysed protein and medium chain triglycerides. An increase in the length of the villi seen shortly after commencement of the diet was followed by a reduction in the rate of proliferation in the crypt. After 7 days on the diet, an equilibrium state was reached with the cellularity of the villi being 120% that of control while the number of proliferative cells/crypt was reduced by 35%. The proliferative response of the crypt following irradiation occurred 16 hr later in diet-fed mice than in controls. It was postulated that, because of the increased cellularity of the villus compartment in diet-fed mice, additional time was required to reduce the number of villus cells to a critical level at which a proliferative response is induced in the crypt.

References

Jul 1, 1977·Cell and Tissue Kinetics·R P RijkeH M Plaisier
Mar 1, 1975·Cell and Tissue Kinetics·J D Harding, A B Cairnie
Jan 1, 1971·Cell and Tissue Kinetics·E Kivilaakso, T Rytömaa
Nov 1, 1974·Cell and Tissue Kinetics·H S Al-DewachiA J Watson
Jan 1, 1967·Archiv für Mikrobiologie·B E Wright
Nov 1, 1953·Stain Technology·A D CONGER, L M FAIRCHILD

Related Concepts

Cell Density
Cell Division Phases
Diet
Dietary Proteins
Epithelial Cells
Structure of Intestinal Gland
Jejunum
Microvilli
Triglycerides

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