Changes in gut microbiota and plasma inflammatory factors across the stages of colorectal tumorigenesis: a case-control study.

BMC Microbiology
Yongzhen ZhangQingwu Jiang

Abstract

Colorectal cancer (CRC) is a common malignant gastrointestinal tumor. In China, CRC is the 5th most commonly diagnosed cancer. The vast majority of CRC cases are sporadic and evolve with the adenoma-carcinoma sequence. There is mounting evidence indicating that gut microbiota and inflammation play important roles in the development of CRC although study results are not entirely consistent. In the current study, we investigated the changes in the CRC-associated bacteria and plasma inflammatory factors and their relationships based on data from a case-control study of Han Chinese. We included 130 initially diagnosed CRC patients, 88 advanced colorectal adenoma patients (A-CRA), 62 patients with benign intestinal polyps and 130 controls. Fecal microbiota composition was obtained using 16S ribosomal DNA (16S rDNA) sequencing. PCOA analysis showed structural differences in microbiota among the four study groups (P = 0.001, Unweighted Unifrac). Twenty-four CRC-associated bacteria were selected by a two-step statistical method and significant correlations were observed within these microbes. CRC-associated bacteria were found to change with the degree of malignancy. Plasma C-reactive protein (CRP) and soluble tumor necrosis factor II ...Continue Reading

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Citations

Feb 6, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Emilie Palmgren ColovIsmail Gögenur
Dec 5, 2019·World Journal of Clinical Cases·Hussein SabitHuseyin Tombuloglu
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Jun 3, 2021·Microorganisms·Edgar Torres-MaravillaLuis G Bermúdez-Humarán
Dec 7, 2021·Frontiers in Cell and Developmental Biology·Shakhzada IbragimovaSamuel B Ho

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Methods Mentioned

BETA
lavage
ELISA
electrophoresis
PCR
Fluorescence
amplicon sequencing

Software Mentioned

Cytoscape
QIIME
Trimmomatic
Boruta
metagenomeSeq
PMANOVA
SINTAX

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