Changes in Gut Microbiota Composition after Bariatric Surgery: a New Balance to Decode.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Silvia PalmisanoN De Manzini

Abstract

Recently, the link between obesity and gut microbiota has become a focus for research. This study shed some light on the modification of postoperative gut microbial composition after bariatric surgery. A prospective longitudinal study on healthy lean subjects and patients who underwent bariatric surgery (Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy) was carried out. Anthropometric and metabolic data, smoking, food preferences data, and stool samples were collected from lean subjects and from obese patients before and 3 and 6 months after surgery (T0, T3, and T6, respectively). We collected stool samples from 25 obese patients before surgery and 3 and 6 months thereafter and from 25 normal weight patients. After Roux-en-Y gastric bypass, Yokenella regensburgei (p < 0.05), Fusobacterium varium (p < 0.05), Veillonella dispar/atypica (p < 0.05), and Streptococcus australis/gordonii (p < 0.05) were transiently identified in the gut at T3. Roux-en-Y gastric bypass patients had a permanent increase in Akkermansia muciniphila (p < 0.05), which is associated with healthy metabolism, both at T3 and T6. There were no significant changes in gut microbiota in laparoscopic sleeve gastrectomy patients. In our study, Roux-en-Y ...Continue Reading

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Citations

Apr 7, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Elisa Morales-MarroquinSarah E Messiah
Apr 30, 2020·Nutrients·Silke CrommenMarie-Christine Simon
Nov 10, 2020·Frontiers in Oncology·Chunye ZhangAaron C Ericsson
Feb 24, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Tomasz StefuraPiotr Major
Mar 12, 2021·Frontiers in Nutrition·Maria do Carmo Gouveia PeluzioFermín I Milagro
Jul 22, 2021·Reviews in Endocrine & Metabolic Disorders·Carolina Gutiérrez-RepisoFrancisco J Tinahones
Aug 8, 2021·Endocrine Reviews·Elina AkalestouCarel W le Roux
Oct 30, 2021·Current Opinion in Organ Transplantation·Hao Zhou, Stefan G Tullius

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