Changes in Gut Microbiota May Be Early Signs of Liver Toxicity Induced by Epoxiconazole in Rats.

Chemotherapy
Cheng XuZhaoyan Jiang

Abstract

The gut microbiome is essential for human health due to its effects on disease development, drug metabolism and the immune system. It may also play a role in the interaction with environmental toxicants. However, the effect of epoxiconazole, a fungicide active ingredient from the class of azoles developed to protect crops, on the abundance and composition of the gut microbiome has never been studied. We put forward the hypothesis that changes in gut microbiota may be early signs of toxicity induced by epoxiconazole. In this study, female rats were fed with epoxiconazole-adulterated diets (0, 4 and 100 mg/kg/day) for 90 days. The gut microbiome was determined by 16S rRNA gene sequencing. Body and organ weight, and blood biochemistry were also measured after 90 days of oral epoxiconazole exposure. Interestingly, the abundance of gut Firmicutes decreased, and Bacteroidetes and Proteobacteria increased. At family level, Lachnospiraceae and Enterobacteriaceae were selectively enriched following epoxiconazole exposure. Our results indicate that epoxiconazole exposure may induce changes in the gut microbiome and potential liver toxicity. Changes in the gut microbiome may be used as early indicators for monitoring the health risk of th...Continue Reading

Citations

Apr 8, 2017·Environmental Science and Pollution Research International·Cheng XuAihua Gu
Jan 14, 2017·Environmental Pollution·Yuanxiang JinZhengwei Fu
Jun 22, 2019·International Journal of Toxicology·Jason M KoontzJohn A Lewis
Sep 26, 2020·Frontiers in Public Health·Sébastien DuperronBenjamin Marie
May 12, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karen ChiuWenyan Mei
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wuwen FengCheng Peng
Oct 17, 2020·Critical Reviews in Food Science and Nutrition·Moamen M ElmassryMohamed A Farag
Jun 3, 2021·International Journal of Environmental Research and Public Health·Federica GiambòConcettina Fenga
Sep 10, 2020·Journal of Agricultural and Food Chemistry·Zhiyuan MengWentao Zhu
Sep 21, 2021·Applied Microbiology and Biotechnology·Mercedes Quintanilla-MenaCarlos Puch-Hau

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