Changes in Health-Related Quality of Life in People With Intellectual Disabilities Who Discontinue Long-Term Used Antipsychotic Drugs for Challenging Behaviors

Journal of Clinical Pharmacology
Lotte RamermanGerda M de Kuijper

Abstract

Health-related quality of life in people with intellectual disabilities can be affected by challenging behaviors and side effects of antipsychotics. The aim of this study was to evaluate the effect of discontinuation antipsychotic drugs on health-related quality of life, including data from 2 discontinuation trials: an open-label trial of various antipsychotic drugs and a double-blind trial of risperidone. In both studies, antipsychotics were discontinued in 14 weeks, with steps of 12.5% of the baseline dosage every 2 weeks. Health-related quality of life was measured at baseline and at 16 weeks, and 40 weeks after baseline, by means of the RAND-36 (domains on physical well-being, role limitations caused by physical or emotional problems, vitality, pain, mental well-being, social functioning, general health, and changes in health). Participants who had completely discontinued antipsychotics according to the scheduled discontinuation and were still free of use at 40 weeks were compared with those who had incompletely discontinued. Physical well-being showed an increase in the group that had achieved complete discontinuation. Social functioning showed a decrease in the group that incompletely discontinued, which recovered at foll...Continue Reading

References

May 2, 2000·The British Journal of Psychiatry : the Journal of Mental Science·Z AhmedJ Thomas
Aug 9, 2001·Annals of Medicine·R D Hays, L S Morales
Mar 29, 2003·Psychiatric Services : a Journal of the American Psychiatric Association·David B AllisonDiana D McDonnell
Dec 5, 2006·Schizophrenia Research·Guy FaulknerHyacinth Irving
Apr 30, 2010·Journal of Intellectual Disability Research : JIDR·Gerda de KuijperH Evenhuis
Jun 29, 2010·Research in Developmental Disabilities·Johnny L Matson, Sara Mahan
Jun 25, 2013·Research in Developmental Disabilities·Gerda de KuijperPieter J Hoekstra
Feb 15, 2014·World Journal of Clinical Cases·Crispin Schneider, David F Hewin
Feb 15, 2014·World Journal of Clinical Cases·Federico GobbiZeno Bisoffi
Feb 15, 2014·World Journal of Clinical Cases·Elena LionettiMario La Rosa
Jun 1, 2017·Journal of Intellectual Disability Research : JIDR·G M de Kuijper, P J Hoekstra
Jun 24, 2017·Journal of Intellectual Disability Research : JIDR·M O'DwyerM C Henman

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