Changes in Healthcare Spending After Diagnosis of Comorbidities Among Endometriosis Patients: A Difference-in-Differences Analysis

Advances in Therapy
Andrew J EpsteinEric S Surrey

Abstract

We sought to characterize changes in healthcare spending associated with the onset of 22 endometriosis-related comorbidities. Women aged 18-49 years with endometriosis (N = 180,278) were extracted from 2006-2015 de-identified Clinformatics® DataMart claims data. For 22 comorbidities, comorbidity patients were identified on the basis of having a first comorbidity diagnosis after their initial endometriosis diagnosis. Controls were identified on the basis of having no comorbidity diagnosis and were matched 1:1 to comorbidity patients on demographics and baseline spending. Total medical and pharmacy spending was measured during 12 months before and after each patient's index date (first comorbidity diagnosis for comorbidity patients, and equal number of days after earliest endometriosis claim for controls). Pre-post spending differences were compared using difference-in-differences linear regression. Total and comorbidity-related cumulative spending per patient for all endometriosis patients were calculated annually for the 5 years following endometriosis diagnosis. The number of endometriosis patients with each comorbidity varied between 121 for endometrial cancer and 16,177 for fatigue. Healthcare spending increased significantl...Continue Reading

References

Jun 1, 1997·Obstetrics and Gynecology Clinics of North America·B Eskenazi, M L Warner
Sep 1, 1997·Clinical Immunology and Immunopathology·D L JacobsonN M Graham
Jun 23, 2007·Human Reproduction Update·S SimoensT D'Hooghe
Jun 19, 2009·The Canadian Journal of Cardiology·Jean-Eric TarrideRon Goeree
Dec 9, 2009·Fertility and Sterility·Anderson Sanches MeloCarolina Sales Vieira
Jun 23, 2010·Obstetrics and Gynecology
Jun 25, 2010·The New England Journal of Medicine·Linda C Giudice
Sep 28, 2010·Statistical Science : a Review Journal of the Institute of Mathematical Statistics·Elizabeth A Stuart
Oct 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·K Robin YabroffAngela Mariotto
Mar 15, 2015·Human Reproduction Update·Marina KvaskoffStacey A Missmer
May 27, 2015·International Forum of Allergy & Rhinology·Patricia A Loftus, Sarah K Wise
Mar 31, 2016·Circulation. Cardiovascular Quality and Outcomes·Fan MuStacey A Missmer
May 25, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F ParazziniS Bianchi
Jul 20, 2016·Gynecologic Oncology·Julie Brøchner MogensenAllan Jensen
Apr 26, 2017·Journal of Women's Health·Ahmed M SolimanMichael C Snabes
May 10, 2017·Fertility and Sterility·Ahmed M SolimanJane Castelli-Haley
Jun 29, 2017·Seminars in Reproductive Medicine·Myles H AldermanHugh S Taylor

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BETA
hysterectomy

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Stata MP

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