Changes in hemocoagulation in acute stroke patients after one-hour sono-thrombolysis using a diagnostic probe

Ultrasound in Medicine & Biology
David SkoloudíkRoman Herzig

Abstract

The aim was to monitor the changes in hemocoagulation parameters in acute ischemic stroke (AIS) patients after sono-thrombolysis of the occluded middle cerebral artery using a duplex transcranial probe with 2.0-MHz frequency in Doppler mode. Sixteen AIS patients indicated for intravenous thrombolysis (IVT) (8 males; mean age 68.3 +/- 7.1 y) and 16 AIS patients contraindicated for IVT (11 males; mean age 67.9 +/- 7.9 y) were randomized for sono-thrombolysis (8 + 8 patients) or standard treatment (control group) (8 + 8 patients). The significant decrease of plasminogen activator inhibitor-1, plasminogen and alpha-2-antiplasmin activity by a mean of 60, 32 and 24%, respectively, and the increase of tissue plasminogen activator by a mean of 56% was found after sono-thrombolysis when compared with control group (p < 0.0125); these changes were more evident in patients treated with a combination of sono-thrombolysis and IVT (79, 38, 50 and 82%, respectively) than in patients treated by sono-thrombolysis alone (34, 13, 17 and 30%, respectively).

References

Nov 1, 1992·The Journal of Clinical Investigation·C W FrancisV J Marder
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Toshihiro IshibashiHiroshi Furuhata
Oct 24, 2002·Journal of the American College of Cardiology·Kelly L DunnSamuel Z Goldhaber
Jun 5, 2003·Annals of Neurology·Jürgen EggersGünter Seidel
Mar 23, 2005·Neurology·Jürgen EggersInke R König
Nov 23, 2005·Seminars in Vascular Medicine·Gordon D O Lowe
Apr 29, 2006·Stroke; a Journal of Cerebral Circulation·Matthias ReinhardThomas Els
Jun 6, 2006·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·D ToniM Prencipe
Jan 16, 2007·Ultrasound in Medicine & Biology·Stanley B BarnettMarvin Ziskin
Jan 24, 2007·Ultrasound in Medicine & Biology·Stanley B Barnett
Aug 1, 2007·Journal of Thrombosis and Thrombolysis·David SkoloudíkPetr Kanovský
May 15, 2008·Cerebrovascular Diseases·UNKNOWN European Stroke Organisation (ESO) Executive Committee, UNKNOWN ESO Writing Committee
May 20, 2008·Ultrasound in Medicine & Biology·Douglas L MillerRoger C Wiggins
Aug 19, 2008·Acta Neurologica Scandinavica·E Haapaniemi, T Tatlisumak
Feb 25, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·Andrew D BarretoCarlos A Molina
Mar 28, 2009·Stroke; a Journal of Cerebral Circulation·Paul Syme
Aug 12, 2009·Annals of Neurology·Carlos A MolinaAndrei V Alexandrov

❮ Previous
Next ❯

Citations

Jul 6, 2014·Expert Review of Neurotherapeutics·Michal HaršányAndrei V Alexandrov
Jan 10, 2014·Expert Opinion on Drug Delivery·Marie de Saint VictorEleanor Stride
Aug 23, 2016·Expert Opinion on Biological Therapy·Aldo BonaventuraFranco Dallegri
Nov 7, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Petr BardonDavid Skoloudik
Apr 24, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Maher SaqqurAndrei V Alexandrov
Oct 24, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Petr BardoňDavid Školoudík

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.