Changes in hemodynamics and left ventricular structure after menopause

The American Journal of Cardiology
Alan L HinderliterRobert Waugh

Abstract

To evaluate the cardiovascular changes associated with menopause, we studied hemodynamics at rest, ambulatory blood pressure, and left ventricular structure in a biracial cohort of pre- and postmenopausal women of similar age, race, weight, and blood pressure. Despite similar levels of blood pressure, postmenopausal women had a higher indexed peripheral resistance (2,722 +/- 757 vs 2,262 +/- 661 dynes.s.m(2)/cm(5), p <0.01) and a lower cardiac index (2.64 +/- 0.73 vs 3.10 +/- 0.71 L/min.m(2), p <0.01) than premenopausal women. Postmenopausal women also had less nocturnal decreases in both systolic (15 +/- 8 vs 19 +/- 8 mm Hg, p <0.01) and diastolic (12 +/- 6 vs 15 +/- 6 mm Hg, p = 0.05) pressures during ambulatory monitoring and higher levels of hematocrit (40 +/- 2% vs 38 +/- 3%, p <0.01). In association with this greater hemodynamic load, postmenopausal women had evidence of early concentric left ventricular remodeling, manifested by a greater relative wall thickness (0.38 +/- 0.06 vs 0.35 +/- 0.06, p <0.01) than that observed in premenopausal women. Differences between pre- and postmenopausal women in hemodynamics, diurnal blood pressure variation, and left ventricular structure were observed in white and African-American su...Continue Reading

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Citations

Aug 23, 2007·British Journal of Sports Medicine·Ross Q OsbornGerald Fletcher
Sep 23, 2009·Menopause : the Journal of the North American Menopause Society·Andrew SherwoodJudith McFetridge-Durdle
Jul 2, 2014·Journal of Molecular and Cellular Cardiology·Lu-Yao SunBao-Feng Yang
Jan 29, 2005·Annals of the New York Academy of Sciences·Kenneth G WaltonRobert H Schneider
Jun 4, 2014·The Journal of Obstetrics and Gynaecology Research·Raziye Keskin KurtIbrahim H Tanboga
Apr 5, 2015·American Journal of Hypertension·Zi YeIftikhar J Kullo
Apr 6, 2004·Journal of the American College of Cardiology·Manish G AminMark J Sarnak
Dec 3, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Chutima RattanasopaTepmanas Bupha-Intr
May 12, 2011·Journal of Hypertension·Giovanni De SimoneBarbara V Howard
Nov 7, 2002·Current Hypertension Reports·Enrique Z FismanAmos Pines
Oct 30, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Mehmet Akif DüzenliMehmet Tokac
Jun 23, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Joel DanielPeter S McFetridge
Jan 22, 2005·Journal of Hypertension·Paula J HarveyJohn S Floras
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Sep 5, 2018·BMC Complementary and Alternative Medicine·Zhiguo ZhangYanjing Chen
May 4, 2021·The Chinese Journal of Physiology·Theerachat KampaengsriTepmanas Bupha-Intr
Jun 16, 2021·Menopause : the Journal of the North American Menopause Society·Wendy YingDhananjay Vaidya

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