PMID: 7334359Jan 1, 1981Paper

Changes in hepatitis B virus DNA-polymerase activity in patients with chronic infection

Journal of Medical Virology
A AlbertiG Realdi

Abstract

Levels of serum hepatitis B virus DNA-polymerase (HBV-DNAP) were studied longitudinally over variable periods of time in 16 HBV chronic carriers using a modified assay procedure developed to increase reproducibility. Ten patients were tested on a short-term basis at 3- to 6-hr intervals for 48 hr or at 24- to 48-hr intervals for 15 consecutive days, and all showed marked vacillations in enzyme levels although hospitalized and untreated. Patients with chronic active hepatitis on liver biopsy had larger fluctuations compared to cases of chronic persistent hepatitis. Six patients were longitudinally tested over a period of 12-32 months and those three receiving immunosuppressive drugs showed a progressive increase in DNAP levels during therapy, but two returned to pretreatment levels after therapy was withdrawn and one even cleared permanently the complete virus with seroconversion to anti-HBe. Such outcome was also observed in one patient with chronic active hepatitis who remained untreated.

References

Jan 1, 1979·Comparative Immunology, Microbiology and Infectious Diseases·G CastrucciB Tesei
Apr 21, 1978·JAMA : the Journal of the American Medical Association·R B PollardW S Robinson
Aug 19, 1978·British Medical Journal·R G ChadwickS Sherlock
Jan 1, 1978·Journal of Medical Virology·C R Howard
Sep 2, 1976·The New England Journal of Medicine·H B GreenbergT C Merigan
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Mar 1, 1976·Journal of Virology·P M KaplanJ L Gerin
Nov 1, 1973·Journal of Virology·P M KaplanW S Robinson

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Citations

Mar 1, 1993·Journal of Medical Virology·Y Lazizi, J Pillot
Nov 1, 1983·Digestive Diseases and Sciences·A AlbertiG Realdi
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A AlbertiG Realdi
May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A BudkowskaJ Pillot
Mar 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MondelliA Alberti
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hyung Joon Yim, Anna Suk-Fong Lok
Jun 1, 1990·Journal of Virology·R BchiniM A Petit

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