PMID: 489263Jan 1, 1979Paper

Changes in hippocampal neuronal nuclei in response to environmental stimulation

The International Journal of Neuroscience
R N Walsh, R A Cummins

Abstract

The diameter of cortical neuronal nuclei has been reported to increase when animals are reared in enriched, as opposed to deprived, sensory environments. The present study investigated whether analogous neuronal changes occur in the hippocampus. Male Wistar rats were reared in either an enriched or a deprived environment for 80 days after weaning. At the completion of this rearing period both brain weights and hippocampal neuronal nuclear diameters were measured. The enriched subjects exhibited a greater forebrain:hindbrain ratio (3.7% p less than 0.05) when compared to the isolated subjects. No significant differences in mean hippocampal nuclear dimensions could be detected but variability in nuclear size was greater in the stratum granulosum of the isolated subjects (p less than 0.01). It is proposed that this increased variability reflects an environmentally restricted development of these neurons.

References

Aug 12, 1977·Science·R A CumminsJ G Evans
Jan 1, 1976·Journal of Neurobiology·M C DiamondM R Rosenzweig
Jan 1, 1973·Developmental Psychobiology·R N WalshO E Budtz-Olsen
Jun 29, 1973·Nature·R A CumminsC R Horsfall
Nov 1, 1969·The Journal of Comparative Neurology·R N WalshR A Cummins

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Citations

Jan 1, 1980·Progress in Neurobiology·D G Jones, B J Smith
Feb 1, 1985·Biological Psychology·J LeahR Cummins
Jan 1, 1981·The International Journal of Neuroscience·R N Walsh
Aug 14, 2012·Neurobiology of Aging·Inês Tomás PereiraPeter R Rapp
Jan 21, 2016·Cell Transplantation·Ji Hea YuSung-Rae Cho
Mar 22, 2001·Nature Reviews. Neuroscience·H van PraagF H Gage
Jan 3, 2014·Physiological Reviews·Alessandro SaleLamberto Maffei
Feb 7, 2019·Nature Reviews. Neuroscience·Gerd Kempermann

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