Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios

Fertility and Sterility
Odysseas GregoriouGeorgios Creatsas

Abstract

To compare the effects of 2.5 mg letrozole with those of 1 mg anastrazole daily on the hormonal and semen profiles of a subset of infertile men with low T/E(2) ratios. Prospective, nonrandomized study. Reproductive medicine clinic. The study group consisted of 29 infertile men with a low serum T/E(2) ratio (<10). Patients were divided into two groups. Group A included 15 patients treated with 2.5 mg letrozole orally once daily for 6 months, and Group B consisted of 14 patients treated with 1 mg anastrazole orally every day for 6 months. Hormonal evaluation included measurement of serum FSH, LH, PRL, T, and E(2). In all sperm analyses pretreatment and posttreatment total motile sperm counts (ejaculate volume × concentration × motile fraction) were evaluated. The use of aromatase inhibitors (either letrozole or anastrazole) in cases of infertile men with low T/E(2) ratios improved both hormonal and semen parameters. This study suggests that some men with severe oligospermia, low T levels, and normal gonadotropin concentration may have a treatable endocrinopathy.

References

Jan 5, 2002·Radiology·Harriet J PaltielAnthony Atala
Jan 17, 2002·The Journal of Urology·Jay D Raman, Peter N Schlegel
Jul 28, 2005·The Journal of Clinical Endocrinology and Metabolism·Guy G T'SjoenJean-Marc Kaufman
Dec 31, 2005·The New England Journal of Medicine·UNKNOWN Breast International Group (BIG) 1-98 Collaborative GroupAron Goldhirsch
Jun 17, 2008·Fertility and Sterility·Fabio Firmbach PasqualottoEleonora Bedin Pasqualotto
Jun 16, 2009·Fertility and Sterility·Geneviève PatryKirk C Lo

❮ Previous
Next ❯

Citations

Jan 23, 2013·Drug Testing and Analysis·Gary N W LeungPeter J Schiff
Nov 6, 2012·Expert Opinion on Pharmacotherapy·Alaa J HamadaAshok Agarwal
Jun 3, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Wai Him KwokPeter J Schiff
Apr 14, 2016·Asian Journal of Andrology·Joshua D RingTobias S Köhler
Oct 30, 2012·Fertility and Sterility·Peter N Schlegel
Apr 20, 2016·Nature Reviews. Urology·Martin Kathrins, Craig Niederberger
Jun 14, 2016·Current Urology Reports·Darshan P PatelJames M Hotaling
Jan 11, 2017·Fertility and Sterility·Ohad ShoshanyCraig Niederberger
Apr 20, 2016·International Journal of Immunopathology and Pharmacology·Rosita A CondorelliSandro La Vignera
Nov 9, 2018·Expert Opinion on Pharmacotherapy·Ylenia DucaSandro La Vignera
Oct 2, 2020·Minerva endocrinologica·Sandro La VigneraAntonio Aversa
Jun 11, 2018·Current Urology Reports·Robert CarrasquilloRanjith Ramasamy
Jun 1, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cecilie Hurup MunkboelBjarne Styrishave
May 3, 2021·Sexual Medicine Reviews·Omer A RaheemThomas J Walsh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.