PMID: 9541185Apr 16, 1998Paper

Changes in hormone receptors and proliferation markers in tamoxifen treated breast cancer patients and the relationship with response

Breast Cancer Research and Treatment
Andreas MakrisM Dowsett

Abstract

To determine the effects of tamoxifen on the levels of hormone receptors and proliferation markers in the early phase of treatment and the relationship of the changes with tumor response in patients with primary breast cancer. Twenty-one women with primary, operable breast carcinomas were treated with tamoxifen 20 mg daily. Fine needle aspiration (FNA) was used to obtain samples prior to the start and at 14 days and 8-weeks post-treatment. From these samples estrogen receptor (ER), progesterone receptor (PgR), and Ki67 levels were determined using immunocytochemistry and ploidy and S-phase fraction (SPF) using flow cytometry. Tumor response was measured clinically according to UICC criteria. There were 12 responders (2 CR, 10 PR) and 9 non-responders (2 NC, 7 PD). Responders were more likely to be ER+ (p = 0.002), PgR+ (p = 0.006), and low SPF (p = 0.06). At 14 days post-tamoxifen, the median decrease in Ki67 (% cells staining) for responders was -4.8 and for non-responders -0.15 (p = 0.005). This decrease was seen predominantly in ER+ tumours. The difference in SPF was not significant. A decrease in ER was seen in 3/15 patients all of whom were responders. A rise in PgR was seen in 7/17 patients and all but one were responders...Continue Reading

References

Sep 1, 1978·Cancer Treatment Reviews·H MouridsenL Battersby
Mar 1, 1977·British Journal of Cancer·J L HaywardR D Rubens
Apr 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherS Legault-Poisson
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·J GerdesH Stein
Jan 1, 1984·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·R SilvestriniG Di Fronzo
Mar 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J C AllegraR Warren
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P A MurrayR C Coombes
May 1, 1997·Breast Cancer Research and Treatment·A MakrisC K Osborne

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Citations

Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J D GrahamK B Horwitz
Nov 7, 2012·Japanese Journal of Clinical Oncology·Takeshi Yamaguchi, Hirofumi Mukai
Jun 5, 2003·Journal of the National Cancer Institute·Kendall Wu, Powel Brown
Jun 5, 2003·Journal of the National Cancer Institute·Andrea DecensiUmberto Veronesi
Jan 27, 2012·Breast Cancer Research : BCR·William R Miller, Alexey A Larionov
Apr 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G R de LimaL H Gebrim
May 20, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W R MillerT J Anderson
Nov 10, 2005·Clinical Breast Cancer·Antonio FrassoldatiPier Franco Conte
Sep 21, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H E FjøsneUNKNOWN Norwegian Breast Cancer Group (NBCG)
Jun 19, 2012·Diagnostic Cytopathology·Pedro Vitor Lopes-CostaBenedito Borges da Silva
Jan 3, 2013·International Journal of Cancer. Journal International Du Cancer·Neill PataniMitch Dowsett
Sep 10, 2009·International Journal of Cancer. Journal International Du Cancer·Eleanor GutteridgeJulia Gee
May 12, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B de CastilloM Norman
Jul 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·William R MillerJ M Dixon
Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·S IqbalW R Miller
Dec 3, 2014·Clinical Breast Cancer·John F R RobertsonJulia M W Gee
May 17, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Meenakshi SinghPaul A Seligman
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ander UrruticoecheaMitch Dowsett
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine L Harper-WynneMitchell Dowsett
Jan 5, 2019·Advanced Pharmaceutical Bulletin·Behnaz Faramarzian Azimi MaraghehHojjatollah Nozad Charoudeh
Jul 26, 2002·Psychosomatic Medicine·Linda D CameronLinda J Patrick-Miller
Apr 3, 1999·International Journal of Cancer. Journal International Du Cancer·S DetreM Dowsett
Mar 29, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A C Wolff, N E Davidson
Mar 16, 2004·Annals of Surgical Oncology·E Shelley Hwang, Laura Esserman
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carol J FabianDoris Browne
Jan 21, 2004·The Breast : Official Journal of the European Society of Mastology·R A HawkinW R Miller

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