Changes in hypothalamic neurotransmitter uptake following pinealectomy, superior cervical ganglionectomy or melatonin administration to rats

Neuroendocrinology
D P Cardinali

Abstract

Rats subjected to pinealectomy or to pinealectomy plus bilateral superior cervical ganglionectomy exhibited depressed serotonin uptake by hypothalamic synaptosomes; norepinephrine, dopamine or glutamate uptake was not affected by any of the surgical procedures. Treatment with melatonin resulted in inhibition of hypothalamic serotonin accumulation but it did not modify the uptake of norepinephrine, dopamine or glutamate. These data suggest a relationship between the pineal gland and the serotoninergic nerve endings of the hypothalamus.

Citations

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Related Concepts

Metazoa
Intropin
Autonomic Ganglion
Glutamic Acids
Organum Vasculosum Laminae Terminalis
Melatonin
Norepinephrine, (+, -)-Isomer
Pineal Gland
Hydroxytryptamine
Synaptosomes

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