Changes in hypothalamic neurotransmitter uptake following pinealectomy, superior cervical ganglionectomy or melatonin administration to rats

D P Cardinali


Rats subjected to pinealectomy or to pinealectomy plus bilateral superior cervical ganglionectomy exhibited depressed serotonin uptake by hypothalamic synaptosomes; norepinephrine, dopamine or glutamate uptake was not affected by any of the surgical procedures. Treatment with melatonin resulted in inhibition of hypothalamic serotonin accumulation but it did not modify the uptake of norepinephrine, dopamine or glutamate. These data suggest a relationship between the pineal gland and the serotoninergic nerve endings of the hypothalamus.


Jan 1, 1981·Journal of Neural Transmission·D P CardinaliP V Gejman
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R W StegerA Bartke
Aug 1, 1977·Psychological Medicine·P E Mullen, R E Silman
Nov 1, 1991·Visual Neuroscience·C K Mitchell, D A Redburn
Jan 16, 1998·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·R Sandyk
Sep 1, 1991·Journal of Pineal Research·J M MíguezM Aldegunde
Dec 1, 1994·The International Journal of Neuroscience·R Sandyk, L C Dann
Feb 1, 1996·The International Journal of Neuroscience·R Sandyk
Mar 1, 1996·The International Journal of Neuroscience·R Sandyk
Dec 1, 1995·The International Journal of Neuroscience·R Sandyk
Nov 1, 1995·The International Journal of Neuroscience·R Sandyk
Jan 28, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sergio F Sánchez Bruni, Gabriela B Acosta
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Steven D Fenster, Craig C Garner

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