Changes in IgE-mediated allergy to ubiquitous inhalants after removal from or diminution of exposure to the agent causing occupational asthma

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
L PerfettiJ L Malo

Abstract

One possibility, among others, for explaining the persistence of asthma symptoms in occupational asthma (OA) after the cessation of exposure to the causal agents may be that subjects become sensitized to ubiquitous inhalants. The aim of this study was to evaluate the development or increase of IgE-mediated sensitization to ubiquitous allergens, both to high- and low-molecular-weight agents, in 100 subjects with OA after cessation of exposure. Subjects were evaluated on a first visit, at the time of diagnosis of OA, coinciding with the cessation or diminution of exposure to the causal agent, and on a second visit, 5.8+/-3.3 years afterwards. At each visit, a history of ocular, nasal and asthmatic symptoms related to exposure to common allergens was obtained together with spirometry and assessment of bronchial responsiveness to methacholine. We analysed total IgE and specific IgE to Dermatophagoides farinae, D. pteronyssinus, birch, ragweed and timothy grass pollens, cat and dog danders, and Alternaria, using enzyme allergosorbent test (EAST) from blood samples taken on each visit. Total IgE levels showed a tendency to diminish. No changes were found in the number of positive EAST (presence of detectable levels of specific IgE) o...Continue Reading

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Citations

Jan 27, 2006·American Journal of Respiratory and Critical Care Medicine·George PiligianElizabeth Wilk-Rivard
Jan 30, 2003·American Journal of Respiratory and Critical Care Medicine·Moira Chan-YeungUNKNOWN American Thoracic Society
Oct 28, 2003·American Journal of Respiratory and Critical Care Medicine·Karim MaghniJean-Luc Malo
Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri
Jan 11, 2018·Allergy·I DávilaM Torrecillas

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