Changes in Immunoreactivity of Sensory Substances within the Enteric Nervous System of the Porcine Stomach during Experimentally Induced Diabetes

Journal of Diabetes Research
Michał BulcLukasz Zielonka

Abstract

One of the most frequently reported disorders associated with diabetes is gastrointestinal (GI) disturbance. Although pathogenesis of these complications is multifactorial, the complicity of the enteric nervous system (ENS) in this respect has significant importance. Therefore, this paper analysed changes in substance P- (SP-), calcitonin gene-related peptide- (CGRP-), and leu5-enkephalin- (L-ENK-) like immunoreactivity (LI) in enteric stomach neurons caused by chemically induced diabetes in a porcine model. Using double immunofluorescent labelling, it was found that acute hyperglycaemia led to significant changes in the chemical coding of stomach enteric neurons. Generally, the response to artificially inducted diabetes depended on the "kind" of enteric plexus as well as the stomach region studied. A clear increase in the percentage of neurons immunoreactive to SP and CGRP was visible in the myenteric plexus (MP) in the antrum, corpus, and pylorus as well as in the submucosal plexus (SmP) in the corpus. For L-ENK, an increase in the number of L-ENK-LI neurons was observed in the MP of the antrum and SmP in the corpus, while in the MP of the corpus and pylorus, a decrease in the percentage of L-ENK-LI neurons was noted.

References

Jan 1, 1991·European Journal of Nuclear Medicine·M HorowitzD J Shearman
Oct 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K Nihei, T Iwanaga
Dec 1, 1982·The American Journal of Physiology·P J ThorS J Konturek
May 6, 1996·Journal of the Autonomic Nervous System·A BelaiG Burnstock
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Oct 23, 1997·Digestive Diseases and Sciences·M LördalP M Hellström
Sep 8, 2001·Drug Discovery Today·J Fricker
Jan 5, 2002·Current Opinion in Pharmacology·P Holzer, U Holzer-Petsche
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Marianne O LarsenBidda Rolin
Apr 30, 2003·Diabetes Care·Aaron I VinikRoy Freeman
Feb 3, 2004·Current Topics in Medicinal Chemistry·Prasanna DatarGirjesh Govil
Dec 8, 2005·Biochemical and Biophysical Research Communications·Ryan J ArnerC Channa Reddy
Apr 21, 2006·Autonomic Neuroscience : Basic & Clinical·Valentina VasinaRoberto De Giorgio
Dec 8, 2006·Annals of the New York Academy of Sciences·Erzsébet FehérTivadar Zelles
Nov 1, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B Chandrasekharan, S Srinivasan
Oct 19, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael CamilleriGianrico Farrugia
Mar 7, 2012·Nature Reviews. Gastroenterology & Hepatology·John B Furness
Jul 6, 2014·Advances in Experimental Medicine and Biology·John B FurnessHyun-Jung Cho
Jul 2, 2015·World Journal of Diabetes·Akram T Kharroubi, Hisham M Darwish
Jan 7, 2016·Frontiers in Cellular Neuroscience·Judyta K JuranekAnn Marie Schmidt
Feb 17, 2017·Handbook of Experimental Pharmacology·James J Galligan, Catia Sternini
Mar 21, 2018·International Journal of Molecular Sciences·Kamila SzymanskaSlawomir Gonkowski

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Citations

Sep 22, 2019·Digestive Diseases and Sciences·Alexandra SelbyFrank K Friedenberg
Jun 28, 2019·Therapeutic Advances in Gastroenterology·Theresa MeldgaardAsbjørn Mohr Drewes
Jul 28, 2020·Toxins·Sławomir GonkowskiKrystyna Makowska
Apr 17, 2019·International Journal of Molecular Sciences·Michał BulcJarosław Całka
Jun 24, 2020·Peptides·Richard J Bodnar

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