PMID: 9546275Apr 18, 1998Paper

Changes in immunostaining of inner ears after antigen challenge into the scala tympani

The Laryngoscope
I IchimiyaG Mogi

Abstract

To study the mechanisms of immune responses and immune injuries in inner ears, labyrinthitis was induced by inoculation of keyhole limpet hemocyanin (KLH) into the scala tympani of systemically sensitized guinea pigs. Inner ears were then immunostained for KLH, immunoglobulin G (IgG), albumin, connexin26 (Cx26), and sodium-potassium adenosine triphosphate (Na,K-ATPase). Inflammatory cells containing KLH were observed in the scala tympani and in the collecting venule of the spiral modiolar vein (SMV). Spiral ligament, spiral limbus, and blood vessels including the SMV were diffusely positive for IgG and albumin. Immunoreactivity for Cx26 and Na,K-ATPase was decreased compared with the normal ears in the fibrocytes of the spiral ligament. These results suggest that inflammatory cells and blood constituents could extravasate into the cochlea from blood vessels and that fibrocyte damage in the spiral ligament could cause cochlear dysfunction.

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Citations

Mar 15, 2011·Journal of the Association for Research in Otolaryngology : JARO·Shanthini MahendrasingamDavid N Furness
Nov 14, 2000·International Journal of Pediatric Otorhinolaryngology·I IchimiyaG Mogi
Dec 22, 1999·Hearing Research·I IchimiyaG Mogi
Feb 17, 2000·Hearing Research·T SukoG Mogi
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Jan 12, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kerem PolatSuphi Müderris
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Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Gregory C BarkdullJeffrey P Harris
Jan 10, 2012·International Journal of Pediatric Otorhinolaryngology·Ismail Önder UysalSuphi Müderris
Jun 4, 2004·The Annals of Otology, Rhinology, and Laryngology·José Ramón García-BerrocalDavid Lobo
Aug 28, 2003·The Annals of Otology, Rhinology, and Laryngology·Issei IchimiyaGoro Mogi
Dec 25, 2002·The Annals of Otology, Rhinology, and Laryngology·Toshiki ShimazakiGoro Mogi
Nov 27, 2002·The Annals of Otology, Rhinology, and Laryngology·José Ramón García Berrocal, Rafael Ramírez-Camacho
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Jun 19, 2007·Acta Oto-laryngologica·Masaomi MoriyamaMasashi Suzuki
Apr 24, 2002·The Annals of Otology, Rhinology & Laryngology. Supplement·Cuneyt M AlperTomonori Takasaka

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