PMID: 11321683Apr 26, 2001Paper

Changes in indices of airway hyperresponsiveness during one year of treatment with inhaled corticosteroids in patients with asthma

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
T OgaA Ikeda

Abstract

We analyzed the changes in indices of airway hyperresponsiveness, including hypersensitivity and hyperreactivity, during one year of treatment with inhaled corticosteroids. We then investigated on which of them the inhaled corticosteroids had a primary effect. Fifty outpatients with asthma were recruited and treated with inhaled beclomethasone dipropionate. They underwent bronchoprovocation tests on the initial visit and at 3, 6, and 12 months. The dose of methacholine required to produce a 20% fall in the forced expiratory volume in 1 second (PD20-FEV1) was measured to evaluate airway hypersensitivity. A relatively novel index, the percent change in the forced vital capacity (deltaFVC%) at the PD20-FEV1, was assessed as a marker of airway hyperreactivity. PD20-FEV1 and deltaFVC% were assumed to indicate the horizontal shift of the dose-response curve and the vertical change in the maximal response plateau, respectively. Log(PD20-FEV1) and deltaFVC% continued to improve throughout the year (p < 0.001 and p = 0.002, respectively). Log(PD20-FEV1) improved significantly at the 3-month evaluation (p < 0.001), and deltaFVC% improved at the 6-month evaluation (p = 0.012). Log(PD20-FEV1) had no or weak relationships with deltaFVC% at ...Continue Reading

References

Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Jan 1, 1989·The American Review of Respiratory Disease·A L JamesJ C Hogg
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·P L EnrightD W Cockroft
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·W J GibbonsP T Macklem
Jun 1, 1997·Respirology : Official Journal of the Asian Pacific Society of Respirology·T K Lim, S M Ang
Aug 26, 1998·Thorax·J LötvallP O'Byrne
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·W BusseS Banks-Schlegel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

© 2021 Meta ULC. All rights reserved