Changes in inflammatory biomarkers after renal revascularization in atherosclerotic renal artery stenosis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Wei WangStephen C Textor

Abstract

Atherosclerotic renal artery stenosis (ARAS) activates oxidative stress and chronic inflammatory injury. Contrast imaging and endovascular stenting pose potential hazards for acute kidney injury, particularly when superimposed upon reduced kidney perfusion. We measured sequential early and long-term changes in circulating inflammatory and injury biomarkers in 12 ARAS subjects subjected to computed tomography imaging and stent revascularization compared with essential hypertensive (EH) subjects of similar age under fixed sodium intake and medication regimens in a clinical research unit. NGAL, TIMP-2, IGFBP7, MCP-1 and TNF-α all were elevated before intervention. Post-stenotic kidney volume, perfusion, blood flow and glomerular filtration rate (GFR) were lower in ARAS than in EH subjects. TIMP-2 and IGFBP7 fell briefly, then rose over 18 h after contrast imaging and stent deployment. Circulating NGAL decreased and remained lower for 27 h. These biomarkers in ARAS returned to baseline after 3 months, while kidney volume, perfusion, blood flow and GFR increased, but remained lower than EH. These divergent patterns of inflammatory signals are consistent with cell cycle arrest (TIMP-2, IGFBP7) and relative protection from acute kidne...Continue Reading

References

Jun 1, 1991·Hypertension·S C Textor, S T Turner
Mar 9, 1995·The New England Journal of Medicine·M Brezis, S Rosen
Nov 25, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D M WilsonR R Liedtke
Oct 14, 2005·Journal of Vascular and Interventional Radiology : JVIR·Timothy P MurphyRalph B D'Agostino
Jan 13, 2006·BMC Genomics·Magali TaulanMarie-Catherine Romey
May 19, 2006·Journal of the American Society of Nephrology : JASN·Prasad Devarajan
Nov 13, 2009·The New England Journal of Medicine·UNKNOWN ASTRAL InvestigatorsJohn Scoble
Nov 4, 2010·Advances in Chronic Kidney Disease·Prasad Devarajan
Nov 16, 2012·Kidney International·Stephen C TextorGustavo S Oderich
Feb 8, 2013·Critical Care : the Official Journal of the Critical Care Forum·Kianoush KashaniJohn A Kellum
Jun 14, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard A Zager
Oct 1, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·James RitchiePhilip A Kalra
Oct 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alfonso EirinLilach O Lerman
Nov 20, 2013·The New England Journal of Medicine·Christopher J CooperUNKNOWN CORAL Investigators
Feb 25, 2014·American Journal of Respiratory and Critical Care Medicine·Azra BihoracJohn A Kellum
Oct 25, 2014·Nephron. Clinical Practice·Nattachai SrisawatJohn A Kellum
Oct 29, 2014·Nature Reviews. Nephrology·Zoltán H Endre, John W Pickering
Dec 24, 2014·Journal of the American Society of Nephrology : JASN·Jay L KoynerUNKNOWN Sapphire Investigators
Apr 15, 2015·Journal of the American Society of Nephrology : JASN·Stephen C Textor, Lilach O Lerman
Apr 22, 2015·BioMed Research International·Wen-Bo ChenShui-Xing Zhang
May 30, 2015·JAMA : the Journal of the American Medical Association·Alexander ZarbockUNKNOWN RenalRIPC Investigators
Jun 6, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John A Kellum, Lakhmir S Chawla

❮ Previous
Next ❯

Citations

Nov 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ahmed SaadStephen C Textor
Jan 19, 2019·Cardiovascular Research·Jing Liu, Jing Wu
May 1, 2019·Current Hypertension Reviews·Chrysoula BoutariAsterios Karagiannis
Sep 5, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Weixuan FanClaudio Ronco
Feb 6, 2017·Current Hypertension Reports·Patricia Van der NiepenAlexandre Persu
Nov 3, 2020·The Annals of Thoracic Surgery·Daniel T EngelmanThomas A Schwann
Jun 3, 2021·Antioxidants·Áine M de BhailísPhilip A Kalra
Feb 8, 2022·Clinical Science·Samer H BarsomLilach O Lerman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.