PMID: 8945970Nov 1, 1996Paper

Changes in insulin action, triglycerides, and lipid composition during sucrose feeding in rats

The American Journal of Physiology
M J PagliassottiD A Pan

Abstract

In the present study, the time course of change in sucrose-induced insulin resistance, triglyceride (TG) concentration, and liver fatty acid composition was examined. Male rats (n = 8-10/group per time point) was fed a high-starch (ST) diet for 2 wk and were then equicalorically fed ST or a high-sucrose (SU) diet for 1, 2, 5, or 8 wk. Body weight and percent body fat were similar between ST and SU diets at all time points. Glucose infusion rate (GIR) was significantly (P < 0.05) lower in the SU diet (9.2 +/- 0.9, 7.4 +/- 0.5, 6.2 +/- 1.0, and 6.0 +/- 0.9 mg.kg-1.min-1) vs. the ST diet (15.1 +/- 1.7, 15.7 +/- 0.7, 14.7 +/- 1.9, and 14.2 +/- 0.9 mg.kg-1.min-1) at 1, 2, 5, and 8 wk, respectively. Reduced suppression of glucose appearance accounted for 85, 50, 45, and 40% of the reduction in GIR at these same time points. Muscle glycogen synthesis was reduced (P < 0.05 vs. ST diet) in the SU diet at 2, 5, and 8 wk. Fasting plasma TG concentration was inversely related (r = -0.79, P < 0.001) to muscle glycogen synthesis, and liver TG concentration was positively related (r = 0.59, P < 0.01) to glucose appearance. Liver fatty acid composition was similar between diet groups. In summary, the SU diet produced insulin resistance in live...Continue Reading

Citations

Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·C LavigneH Jacques
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Y KimJ O Holloszy
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·M E BizeauM J Pagliassotti
Feb 18, 2006·The Journal of Nutrition·Maho SumiyoshiYoshiyuki Kimura
Aug 31, 2017·American Journal of Physiology. Endocrinology and Metabolism·Andrea Lee EstradaMichael J Pagliassotti
Nov 10, 2017·American Journal of Physiology. Endocrinology and Metabolism·Lewin SmallGregory J Cooney
Sep 29, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Benjamin KramerMaria Alicia Carrillo-Sepulveda
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M J PagliassottiC L Morin
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S R CommerfordM J Pagliassotti
May 29, 2003·The Journal of Nutrition·Jérôme BusserollesYves Rayssiguier
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J S ThresherM J Pagliassotti
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Michael J PagliassottiMichael E Bizeau
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Kim-Anne Lê, Luc Tappy
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·S Renee CommerfordMichael J Pagliassotti
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Matthew R JackmanDaniel H Bessesen
Sep 16, 2004·The Korean Journal of Internal Medicine·Sun Min ParkSoo Bong Choi
Sep 16, 2006·American Journal of Physiology. Cell Physiology·Zainisha VasanjiThomas Netticadan
Apr 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Amy J DavidoffJun Ren
Jan 21, 2010·Physiological Reviews·Luc Tappy, Kim-Anne Lê
May 18, 2017·Nutrition Research Reviews·Eva GatineauLaurent Mosoni
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M E BizeauM J Pagliassotti
Jun 17, 2004·American Journal of Physiology. Endocrinology and Metabolism·Yuren Wei, Michael J Pagliassotti
Sep 10, 2011·IUBMB Life·Carlos LarquéMarcia Hiriart
Feb 22, 2012·Journal of Food Science·Young-Mee ChungChi Hye Park
Apr 3, 2014·Molecular Neurobiology·Abigail LopesPatrícia Fernanda Schuck
Jul 21, 2017·Pharmacology & Therapeutics·Donald B JumpSasmita Tripathy
Feb 1, 2003·The Journal of Nutritional Biochemistry·Kristin L MorrisMichael B Zemel
Aug 30, 2005·Metabolism: Clinical and Experimental·Michael E Bizeau, Michael J Pagliassotti
Jul 22, 2021·International Journal of Toxicology·María Eugenia Cervantes-ValenciaTeresa Imelda Fortoul
Oct 15, 2008·Biochimica Et Biophysica Acta·Christopher D MorrisonThomas W Gettys

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