Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men

Journal of Applied Physiology
Sine Haugaard KnudsenRikke Krogh-Madsen

Abstract

A lifestyle characterized by inactivity and a high-calorie diet is a known risk factor for impaired insulin sensitivity and development of Type 2 diabetes mellitus. To investigate possible links, nine young healthy men (24 ± 3 yr; body mass index of 21.6 ± 2.5 kg/m(2)) completed 14 days of step reduction (10,000 to 1,500 steps/day) and overfeeding (+50% kcal). Body composition (dual X-ray absorptiometry, MRI), aerobic fitness (maximal O(2) consumption), systemic inflammation and insulin sensitivity [oral glucose tolerance test (OGTT), hyperinsulinemic euglycemic clamp] were assessed before (day 0), during (days 3 and 7), and immediately after the intervention (day 14), with follow-up tests (day 30). Body weight had increased at days 7 and 14 (P < 0.05). The amount of visceral fat had increased at day 14 compared with day 0 (P < 0.05). The insulin response to the OGTT had increased at days 7 and 14 (P < 0.05). Insulin sensitivity, estimated using the Matsuda index, had decreased at days 3 and 7 (P < 0.01). At day 14, glucose infusion rates had decreased by ∼44% during the euglycemic clamps (P < 0.05). Also, plasma levels of leptin and adiponectin had increased (P < 0.05), whereas no changes were seen in inflammatory markers. At ...Continue Reading

References

Mar 1, 1991·Journal of Applied Physiology·K J MikinesH Galbo
Aug 1, 1988·Metabolism: Clinical and Experimental·C A StuartR R Wolfe
Aug 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G W HeathJ O Holloszy
Dec 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E F CoyleJ O Holloszy
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Jun 1, 1996·The American Journal of Clinical Nutrition·A H ForslundL Hambraeus
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Mar 17, 2001·Medicine and Science in Sports and Exercise·I Mujika, S Padilla
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Anneli Seppälä-LindroosHannele Yki-Järvinen
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Katherine M FlegalClifford L Johnson
Jan 13, 2004·Sports Medicine·Catrine Tudor-Locke, David R Bassett
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Johan HoffstedtPeter Arner
Jul 20, 2005·Diabetes/metabolism Research and Reviews·S R Stannard, N A Johnson
Aug 17, 2005·Current Drug Targets. Cardiovascular & Haematological Disorders·G Iacobellis
Aug 22, 2006·Metabolism: Clinical and Experimental·Marc-Andre CornierDaniel H Bessesen
Nov 24, 2006·Journal of Applied Physiology·Matthew J LayeFrank W Booth
Mar 9, 2007·The Proceedings of the Nutrition Society·Patrick Schrauwen
Oct 13, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Naomi M HamburgJoseph A Vita
Nov 8, 2007·European Journal of Applied Physiology·Frank W BoothJohn P Thyfault
May 8, 2008·Current Opinion in Lipidology·Edward W Kraegen, Gregory J Cooney
Nov 5, 2008·Medicine and Science in Sports and Exercise·Carl J Hulston, Asker E Jeukendrup
Feb 12, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·E CorpeleijnE E Blaak
Apr 1, 2009·The Journal of Physiology·Charlotte BrønsAllan Vaag
Jul 9, 2009·JAMA : the Journal of the American Medical Association·Shanshan LiRob M van Dam
Sep 29, 2009·Nutrition & Metabolism·Rebecca L AdochioMarc-Andre Cornier
Jan 2, 2010·Journal of Applied Physiology·Rikke Krogh-MadsenBente K Pedersen
Feb 20, 2010·Journal of Applied Physiology·Tom R ThomasRichard H Cox
May 25, 2010·Journal of Nutritional Science and Vitaminology·Chiyoko UsuiMitsuru Higuchi
Aug 21, 2010·The Journal of Physiology·Søren NielsenMatthew J Laye
Aug 27, 2010·American Journal of Physiology. Endocrinology and Metabolism·A C AlibegovicA Vaag

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Citations

Sep 29, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T A DinizI F Freitas-Junior
Sep 12, 2015·Current Diabetes Reports·Sine Haugaard Knudsen, Bente Klarlund Pedersen
Sep 26, 2013·Free Radical Research·A Gratas-DelamarcheJ Cillard
Oct 29, 2015·Biogerontology·Oliver PerkinKeith Stokes
Jan 17, 2017·Nature Reviews. Nephrology·Niels Olsen Saraiva CâmaraKumar Sharma
Jan 13, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D J CuthbertsonF Karpe
Jul 20, 2017·European Journal of Clinical Investigation·Bente Klarlund Pedersen
Nov 3, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chris McGloryStuart M Phillips
Mar 29, 2018·PloS One·Anne-Sophie Wedell-NeergaardHelle Bruunsgaard
Jul 7, 2016·American Journal of Physiology. Endocrinology and Metabolism·Philip J AthertonCharles H Lang
Nov 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Signe Tellerup NielsenKirsten Møller
Jan 30, 2019·Medicine and Science in Sports and Exercise·Nathan C WinnJill A Kanaley
Apr 17, 2013·The Journal of Clinical Endocrinology and Metabolism·Leigh BreenStuart M Phillips
Aug 16, 2013·The Journal of Nutrition·Merit LagerpuschAnja Bosy-Westphal
Nov 10, 2013·Journal of Applied Physiology·Rikke Krogh-MadsenBente K Pedersen
Apr 11, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Richard ViskochilBarry Braun
Dec 19, 2015·Journal of Applied Physiology·Signe Tellerup NielsenRikke Krogh-Madsen
Feb 27, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Catrine Tudor-LockeJohn C Spence
May 16, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Tiago PeçanhaBruno Gualano
May 10, 2016·The Journal of Clinical Endocrinology and Metabolism·George A BraySteven R Smith
Apr 5, 2018·Frontiers in Physiology·Yunfang GaoNandu Goswami
Mar 20, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zéphyra AppriouFrédéric Derbré
Jun 11, 2019·Frontiers in Nutrition·Sara Y OikawaStuart M Phillips
Nov 15, 2019·Journal of Exercise Rehabilitation·Kyu Min ParkSunghwun Kang
Aug 18, 2017·Physiological Reviews·Frank W BoothRyan G Toedebusch
Sep 4, 2014·American Journal of Physiology. Endocrinology and Metabolism·Thomas P J SolomonJohn P Kirwan
Dec 6, 2019·Therapeutic Advances in Endocrinology and Metabolism·Kelly A Bowden DaviesDaniel J Cuthbertson

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