Changes in Interhemispheric Motor Connectivity Across the Lifespan: A Combined TMS and DTI Study

Frontiers in Aging Neuroscience
Sebastian StraussMatthias Grothe

Abstract

Age-related decline in interhemispheric connectivity between motor areas has been reported with both transcranial magnetic stimulation (TMS) and diffusion tensor imaging (DTI) measurements. However, not all studies were able to confirm these findings, and previous studies did not apply structural (DTI) and functional (TMS) measurements within each individual appropriately. Here, we investigated age dependency of the ipsilateral silent period (ISP) and integrity of fibers in the corpus callosum as operationalized by fractional anisotrophy (FA), using TMS and DTI, respectively, in 20 participants between 19 and 72 years of age. We found age-dependent increase for ISP, and decrease of FA, both indicating a decrease in interhemispheric inhibition, with a negative association between FA and ISP for the dominant hemisphere (r = -0.39, p = 0.043). Our findings suggest that aging leads to decline of interhemispheric motor connectivity, as evidenced in both structural and functional parameters, which should be taken into account when interpreting disease- or medication-related changes.

References

Jan 1, 1992·The Journal of Physiology·A FerbertC D Marsden
Sep 19, 1998·Electroencephalography and Clinical Neurophysiology·B BoroojerdiJ Noth
Jun 23, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J HöppnerR Benecke
Mar 4, 2003·Journal of Neurophysiology·Robert ChenJie-Yuan Li
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
May 1, 2004·Experimental Brain Research·Carlo TrompettoGiovanni Abbruzzese
May 21, 2005·Brain Research. Brain Research Reviews·R G Carson
Jul 1, 2006·Muscle & Nerve·Patrick Jung, Ulf Ziemann
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mathias WahlUlf Ziemann
Jan 12, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M Cincotta, U Ziemann
Sep 29, 2011·Behavioural Brain Research·Brett W Fling, Rachael D Seidler
Oct 15, 2011·AJNR. American Journal of Neuroradiology·S InanoK Ohtomo
Jan 1, 2011·Brain Connectivity·David H Salat
Aug 14, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Michel Petitjean, Julie Yeung Lam Ko
Dec 12, 2012·Journal of Neurophysiology·Matthew A PetoeCathy M Stinear
Jan 11, 2013·Neural Plasticity·Vincent BeauléHugo Théoret
Apr 15, 2014·Neuroscience and Biobehavioral Reviews·Oron LevinJeffery J Summers
Aug 26, 2014·Neuropsychology Review·Samuel N Lockhart, Charles DeCarli
Mar 26, 2016·Frontiers in Human Neuroscience·Julia LindowMartin Lotze
Jan 13, 2018·Frontiers in Aging Neuroscience·Sahil BajajWilliam D S Killgore

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

EDDY
DARTEL
FNIRT
Signal
_ CORRECT
FSL PROBTRACKX
FSL
FSL BEDPOSTX
SPM12
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.