Changes in intestinal microbiota affect metabolism of ginsenoside Re.

Biomedical Chromatography : BMC
Lei ZhangXiang-Lin Zhang

Abstract

Ginsenoside Re, an active ingredient in Panax ginseng, is widely used as a therapeutic and nutriment. The intestinal microbiota plays crucial roles in modulating the pharmacokinetics and pharmacological actions of ginsenoside Re. The aim of this study was to explore the relationship between bacterial community variety and the metabolic profiles of ginsenoside Re. We developed two models with intestinal dysbacteriosis: a pseudo-germ-free model induced by a nonabsorbable antimicrobial mixture (ATM), and Qi-deficiency model established via over-fatigue and acute cold stress (OACS). First, the bacterial community structures in control, ATM and OACS rats were compared via 16S ribosomal RNA amplicon sequencing. Then, the gut microbial metabolism of ginsenoside Re was assessed qualitatively and quantitatively in the three groups by UPLC-Q-TOF/MS and HPLC-TQ-MS, respectively. Ten metabolites of ginsenoside Re were detected and tentatively identified, three of which were novel. Moreover, owing to significant differences in bacterial communities, deglycosylated products, as the main metabolites of ginsenoside Re, were produced at lower levels in ATM and OACS models. Importantly, the levels of these deglycosylated metabolites correlated w...Continue Reading

References

Oct 6, 2005·Biological & Pharmaceutical Bulletin·Eun-Ah BaeDong-Hyun Kim
Feb 9, 2012·Chinese Medicine·Dacheng PengJingtian Xie
Feb 21, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jin-Yi WanChun-Su Yuan
Dec 28, 2016·Journal of Agricultural and Food Chemistry·Wei-Wei DongLin-Hu Quan

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Citations

Mar 4, 2020·Applied Microbiology and Biotechnology·Wei-Na Li, Dai-Di Fan
Mar 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yanni ZhangYitao Jia
Jun 1, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xi-Yang TangXin-Sheng Yao
Jun 23, 2021·Biomedical Chromatography : BMC·Lei ZhangXiang-Lin Zhang

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