Changes in Intestinal Microbiota of Type 2 Diabetes in Mice in Response to Dietary Supplementation With Instant Tea or Matcha

Canadian Journal of Diabetes
Hai-Hua ZhangShi-Kang Zhang

Abstract

Gut microbiota plays a key role in metabolism and health in diabetes patients with gastrointestinal microbiota dysbiosis. Thus, regulating the ecological balance of gut microbiota may provide a pathway toward improvement for these patients. Our previous study showed that functional ingredients in tea may inhibit cornstarch digestion in vitro. A cornstarch-tea diet was developed, and in this study we investigated the effects of such a diet on blood glucose and gut microbiota in diabetic mice. Diabetes resulted in significant weight loss, hyperphagia and hyperglycemia. 16S rDNA sequencing revealed that in diabetes there is significantly increased Bacteroidaceae, Helicobacteraceae, Ruminococcaceae, Enterobacteriaceae, Rikenellaceae and Saccharibacteria_genera_incertae_sedis, and significantly decreased Lactobacillaceae, Prevotellaceae, Coriobacteriaceae, Verrucomicrobiaceae and Bifidobacteriaceae. The cornstarch‒tea diet resulted in a trend toward reduced blood glucose, with particularly increased levels of Coriobacteriaceae, Lactobacillaceae, Prevotellaceae and Bifidobacteriaceae, and decreased Bacteroidaceae, Ruminococcaceae, Helicobacteraceae and Enterobacteriaceae. Instant tea and matcha supplementation had beneficial effects ...Continue Reading

Citations

Jun 27, 2020·Antioxidants & Redox Signaling·Kenneth R Olson
Apr 15, 2020·International Journal of Food Sciences and Nutrition·Shangfei JiangGuankui Du
Nov 27, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D OzakiN Hitosugi
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joanna KochmanKatarzyna Janda
Jun 13, 2021·Free Radical Biology & Medicine·Ao ShangHua-Bin Li
Jul 3, 2021·Microorganisms·Emanuel VamanuFlorentina Gatea
May 21, 2021·The Journal of Clinical Endocrinology and Metabolism·Ping HuAn Pan
Sep 14, 2021·Critical Reviews in Food Science and Nutrition·Qiqiong Li, Tom Van de Wiele

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