PMID: 3380643Mar 1, 1988Paper

Changes in intracellular ion activities induced by adrenaline in human and rat skeletal muscle

Pflügers Archiv : European journal of physiology
K Ballanyi, P Grafe

Abstract

To study the stimulating effect of adrenaline (ADR) on active Na+/K+ transport we used double-barrelled ion-sensitive micro-electrodes to measure the activities of extracellular K+ (aKe) and intracellular Na+ (aNai) in isolated preparations of rat soleus muscle, normal human intercostal muscle and in one case of hyperkalemic periodic paralysis (h.p.p.). In these preparations, bath-application of ADR (10(-6) M) resulted in a membrane hyperpolarization and transient decreases aKe and aNai which could be blocked by ouabain (3 x 10(-4) M). In the h.p.p. muscle a continuous rise of aNai induced by elevation of aKe to 5.2 mM could be stopped by ADR. In addition, the intracellular K+ activity (aKi), the free intracellular Ca2+ concentration (pCai) and intracellular pH (pHi) were monitored in rat soleus muscle. During ADR aKi increased, pHi remained constant and intracellular Ca2+ apparently decreased. In conclusion, our data show that ADR primarily stimulates the Na+/K+ pump in mammalian skeletal muscle. This stimulating action is not impaired in the h.p.p. muscle.

References

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Citations

Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·E Marcos, J Ribas
Oct 1, 1995·Pflügers Archiv : European journal of physiology·S P CairnsT Clausen
Jun 29, 2011·The Journal of General Physiology·Torben ClausenLawrence J Hayward
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·N FujimuraA Namiki
Nov 1, 1989·Muscle & Nerve·K RickerR Rüdel
Jan 1, 1989·Kidney International·T Clausen, M E Everts
Dec 1, 1989·Muscle & Nerve·J H Williams, W S Barnes
Sep 25, 2003·Physiological Reviews·Torben Clausen
Nov 1, 1991·The American Journal of Physiology·T Clausen, M E Everts
Jan 5, 2021·European Journal of Applied Physiology·Michael I Lindinger, Simeon P Cairns
May 1, 1991·The American Journal of Physiology·J G PickarR C Carlsen
Aug 1, 1990·Journal of Neuroscience Research·K Ballanyi, H Kettenmann

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