Changes in intraocular pressure after intravitreal injections

Vestnik oftalmologii
I A Bubnova, A G Kurguzova

Abstract

At present, intravitreal drug injections are used for treatment of various diseases of posterior segment of the eye. Among its side effects is significant rise of intraocular pressure (IOP). To study the changes in IOP levels after two intravitreal injections. The study was performed on a random selection of 335 patients (335 eyes) diagnosed with choroidal neovascular membrane (CNVM). All the patients received intravitreal injections of ranibizumab according to medical indications. IOP was measured by rebound tonometer Icare-Pro (Icare, Finland) before intravitreal injection, as well as 1 minute, 30 minutes and 3 hours post-injection. Injection was repeated one months after the initial procedure. Intravitreal injection of additional liquid volume causes significant IOP rise, up to 38 mm Hg in average (confidence interval 30-45 mm Hg, p<0.05), with further tendency for IOP to self-normalize. After 30 minutes, IOP remained slightly higher than the initial level - 18 mm Hg (confidence interval 15-21 mm Hg, p<0.05). After 3 hours, IOP approached baseline level - 14 mm Hg (confidence interval 12-16 mm Hg, p<0.05). After the second injection, IOP was observed to decrease slower, causing more patients (28% compared to 21% after the fi...Continue Reading

References

May 2, 2006·Ophthalmology·UNKNOWN VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial GroupB Katz
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Oct 6, 2006·The New England Journal of Medicine·David M BrownUNKNOWN ANCHOR Study Group
Aug 13, 2010·The British Journal of Ophthalmology·Travis J GoodMalik Y Kahook
Apr 24, 2012·Journal of Ophthalmology·Jaclyn L KovachIngrid U Scott
Jul 14, 2012·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Simon E SkalickyAllan Bank
Apr 4, 2013·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Marcel N MenkeSebastian Wolf
Aug 30, 2014·The Cochrane Database of Systematic Reviews·Sharon D SolomonBarbara S Hawkins

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.