PMID: 7027748Jan 1, 1981Paper

Changes in intrarenal sodium handling during saluretic treatment in patients with essential hypertension

Acta Medica Scandinavica
J C RoosP Boer

Abstract

The effect of 50 mg chlorthalidone on blood pressure, body fluid volumes and renal functional parameters was determined in 8 patients with essential hypertension. After 3 days there were signs of volume depletion with little change in mean arterial pressure (MAP). Maximal free water clearance (CH2O) was decreased and fractional proximal sodium reabsorption was increased, but no correlations between these parameters were found. After 3 months there was in inverse relationship between both changes in MAP and the indices of volume depletion and CH2O. It is concluded that when MAP decreases after prolonged saluretic treatment, there is a partial recovery of the initially induced volume depletion and less stimulation of proximal tubular sodium reabsorption. The continuing inhibitory action of chlorthalidone on "distal" sodium reabsorption is partially compensated for, probably by the stimulating effect at this site of the decrease in MAP.

References

Jul 1, 1979·Pflügers Archiv : European journal of physiology·P J Harris
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·T OgiharaA Takagi
Aug 11, 1975·The Journal of Clinical Investigation·R T KunauH L Webb
Oct 1, 1973·The American Journal of Physiology·P C Fernandez, J B Puschett
Jan 1, 1981·European Journal of Clinical Pharmacology·J C RoosE J Dorhout Mees
Jun 1, 1959·The American Journal of Medicine·H O HEINEMANNJ H LARAGH
May 1, 1961·The Journal of Clinical Investigation·L E EARLEYJ ORLOFF
Sep 1, 1965·The Journal of Clinical Investigation·W SUKID W SELDIN
Mar 1, 1965·Clinica Chimica Acta; International Journal of Clinical Chemistry·B A DE PLANQUEE J MEES

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