Changes in ischemic tolerance and effects of ischemic preconditioning in middle-aged rat hearts

Circulation
M TaniY Nakamura

Abstract

Although both clinical and animal studies have shown that ischemic tolerance is reduced in the senescent myocardium, it has not been clarified when myocardium becomes more vulnerable to ischemia. Preconditioning protects the hearts of young adult animals of various species, but its effects are not identical in human studies. We investigated whether ischemic tolerance and the effect of preconditioning decreased in isolated hearts of middle-aged rats. The hearts of young adult rats (12 weeks old: group Y, n = 44) and middle-aged rats (50 weeks old: group M, n = 44) were subjected to global ischemia for 15, 20, or 25 minutes followed by reperfusion. Hearts were also subjected to preconditioning and then to 20 (group Y, n = 22) or 15 (group M, n = 22) minutes of ischemia followed by reperfusion. Left ventricular developed pressure (LVDP) was decreased by 40% to 60%, and the level of ATP was decreased by 60% to 70% in group M compared with group Y. Preconditioning increased LVDP (% LVDP, 40.5% to 72.4%) and levels of high-energy phosphates (ATP, 11.8 to 14.1; creatine phosphate, 17.0 to 23.1 mumol/g dry wt) and reduced left ventricular end-diastolic pressure (LVEDP, 32.8 to 10.3 mm Hg), creatine kinase release (257 to 132 U/g dry wt...Continue Reading

References

May 1, 1977·Journal of Gerontology·G L ColemanA M Jonas
Apr 1, 1979·Toxicology and Applied Pharmacology·D G GoodmanM S Linhart
Jan 1, 1991·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S E FremesT E David
Jan 1, 1990·Fundamental & Clinical Pharmacology·V J RichardK A Reimer
Jul 1, 1990·Journal of the American College of Cardiology·C L Grines, A N DeMaria
Mar 31, 1990·Mechanisms of Ageing and Development·G RaoA Richardson
Aug 1, 1986·Journal of Molecular and Cellular Cardiology·S T RapundaloJ J Feher
Jul 21, 1988·The New England Journal of Medicine·L H EdmundsM B Ratcliffe
Jan 1, 1986·Toxicologic Pathology·H A Solleveld, G A Boorman
Oct 1, 1994·Journal of the American College of Cardiology·R A Kloner, D Yellon
Jul 31, 1993·Lancet·D M YellonW B Pugsley
Jun 1, 1996·Journal of the American College of Cardiology·P AbeteF Rengo

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Citations

Mar 26, 2013·Pflügers Archiv : European journal of physiology·Donna H Korzick, Timothy S Lancaster
Jun 5, 2004·Ageing Research Reviews·Sofija Jovanović, Aleksandar Jovanović
Oct 29, 2003·Experimental Gerontology·Laura WillemsJohn P Headrick
Mar 12, 2004·Mechanisms of Ageing and Development·Sam AlsburyDavid S Latchman
Jul 5, 2003·The Annals of Thoracic Surgery·Babett BartlingAndreas Simm
Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·Mahmoud LoubaniManuel Galiñanes
Jul 1, 1998·Progress in Cardiovascular Diseases·K Przyklenk, R A Kloner
Feb 19, 2002·Mechanisms of Ageing and Development·Harri J RankiAleksandar Jovanović
Oct 26, 1999·Experimental Gerontology·G AzharJ Y Wei
Aug 10, 2000·Journal of the American College of Cardiology·P AbeteF Rengo
Nov 3, 2001·Journal of the American College of Cardiology·R A Kloner
Nov 13, 2001·Journal of the American College of Cardiology·K PrzyklenkP Whittaker
May 22, 2002·Journal of the American College of Cardiology·Pasquale AbeteFranco Rengo
May 25, 2002·Journal of the American Geriatrics Society·Claudio NapoliPasquale Abete
Jan 30, 2009·Cardiovascular Research·Kerstin BoenglerGerd Heusch
May 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G LongobardiF Rengo
Dec 13, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gentian KristoRobert D Lasley
May 22, 2001·The American Journal of Geriatric Cardiology·R A KlonerK Przyklenk
Feb 23, 1999·Fundamental & Clinical Pharmacology·M JoyeuxC Ribuot
Jul 23, 1999·Annals of the New York Academy of Sciences·K PrzyklenkR A Kloner
Oct 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ken ShinmuraRoberto Bolli
May 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Masami KosugeUNKNOWN Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Dec 10, 1999·The Annals of Thoracic Surgery·L P Perrault, P Menasché
Feb 4, 1999·The Annals of Thoracic Surgery·R W LandymoreJ H Fris
Feb 12, 2002·Scandinavian Cardiovascular Journal : SCJ·K Ylitalo, K Peuhkurinen
Nov 22, 2011·Experimental Gerontology·Ragnar HuhnAndré Heinen
Jul 21, 2009·Ageing Research Reviews·Pasquale AbeteFranco Rengo
Jun 11, 2008·Biochemical and Biophysical Research Communications·Kentaro HayashidaKeiichi Fukuda
Mar 3, 2007·The Journal of Pharmacy and Pharmacology·Aleksandar Jovanović

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