PMID: 9175566Mar 1, 1997Paper

Changes in left ventricular mass during treatment with minoxidil and cilazapril in hypertensive patients with left ventricular hypertrophy

Journal of Human Hypertension
G Pogátsa-MurrayS Sonkodi

Abstract

Attainment of the regression of hypertension-associated left ventricular hypertrophy (LVH) seems to be a desirable goal of blood pressure (BP)-reducing therapy. Since antihypertensive drugs of differing types may exhibit markedly different abilities to modulate LVH, we examined the effects of the angiotensin-converting enzyme inhibitor cilazapril, and the potassium channel activator minoxidil, alone or in combination with each other, on the left ventricular mass (LVM) in patients with severe essential hypertension who had LVH detected by echocardiography. All patients received the same base therapy of bopindolol and guanfacine. After a run-in period, they were treated with: (1) cilazapril (n = 10); (2) minoxidil, combined with a diuretic (n = 10); or (3) both cilazapril and monoxidil (n = 6) for 12 months. The LVM index (LVMI; LVM per body surface area) was estimated every 3 months by means of echocardiography. Each kind of therapy decreased the arterial pressures to a similar degree. The 1-year treatment with the cilazapril-based regimen resulted in a significantly diminished LVMI (from a mean +/- s.d. of 173 +/- 38 to 152 +/- 22 g/m2; P < 0.05). On the other hand, the minoxidil-based therapy led to a significant increase in L...Continue Reading

Citations

Jun 21, 2001·The Journal of Clinical Hypertension·D A Sica, T W Gehr
Dec 6, 2000·The Journal of Clinical Investigation·D FatkinJ G Seidman
May 11, 2004·The Journal of Clinical Hypertension·Domenic A Sica
Sep 11, 2016·Progress in Cardiovascular Diseases·Ahmet Afşin OktayMichael E Cash
Jan 13, 2012·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Jorge A Ruivo, Paula Alcântara
Sep 21, 2017·Current Hypertension Reports·Elsayed Z Soliman, Ronald J Prineas
Jan 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Michio Fukuda, Genjiro Kimura
May 22, 2019·Current Hypertension Reports·Jeremy Earl BrooksBharathi Upadhya
Nov 6, 2013·The Journal of Medical Investigation : JMI·Yuko SumiseSeiki Tashiro

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