Changes in leg vein filling and emptying characteristics and leg volumes during long-term head-down bed rest

Journal of Applied Physiology
F LouisyA Güell

Abstract

Leg venous hemodynamics [venous distensibility index (VDI), arterial flow index (AFI), half-emptying time (T1/2)], and leg volumes (LV) were assessed by mercury strain-gauge plethysmography with venous occlusion and volometry, respectively, in seven men before, during, and after 42 days of 6 degrees head-down bed rest. Results showed a high increase in VDI up to day 26 of bed rest (+50% vs. control at day 26, P < 0.05), which tended to subside thereafter (+20% increase vs. control value at day 41, P < 0.05). VDI changes were associated with parallel changes in T1/2 (+54% vs. control at day 26 of bed rest, P < 0.05, and +25% vs. control at day 41, P < 0.05) and with a decrease in AFI (-49% at day 41 vs. P < 0.05). LV continuously decreased throughout bed rest (-13% vs. control at day 41, P < 0.05) but was correlated with VDI only during the first month of bed rest. These results show that during long-term 6 degrees head-down bed rest alterations of leg venous compliance are associated with impairment of venous emptying capacities and arterial flow. Changes in skeletal muscle mass and fluid shifts may account for venous changes during the first month of bed rest but, subsequently, other physiological factors, to be determined, ma...Continue Reading

References

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Citations

Dec 4, 2003·Medicine and Science in Sports and Exercise·Patricia C E De GrootMaria T E Hopman
Dec 6, 2003·Journal of Applied Physiology·M W P BleekerB D Levine
Aug 28, 2004·The Journal of Physiology·Eric Belin de ChantemèlePhilippe Arbeille
Nov 28, 2009·European Journal of Applied Physiology·Dick H J ThijssenDaniel J Green
Oct 24, 2015·Journal of Applied Physiology·Christian M WestbySteven H Platts
Sep 29, 2017·Frontiers in Physiology·Jacques-Olivier FortratClaude Gharib
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A KamiyaI B Kharchenko
Nov 24, 2005·Clinical Science·Jean-Pierre WolfJacques Regnard
Dec 22, 2007·The Journal of Physiology·M KooijmanM T E Hopman
May 3, 2011·European Journal of Applied Physiology·K J Hackney, L L Ploutz-Snyder
Sep 26, 2020·Frontiers in Physiology·Nastassia NavasiolavaMarc-Antoine Custaud
Dec 8, 1998·Journal of Applied Physiology·O BailliartP Vaïda
Mar 15, 2001·Journal of Applied Physiology·D E WatenpaughC G Blomqvist
Aug 23, 2008·European Journal of Applied Physiology·Noortje T L van DuijnhovenMaria T E Hopman
Dec 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Michiel W P BleekerMaria T E Hopman
Jul 31, 2007·European Journal of Applied Physiology·A Pavy-Le TraonJ Vernikos
Jul 23, 2002·Journal of Applied Physiology·Roy FreemanMarcelo Risk
Jul 9, 2011·Journal of Applied Physiology·Dick H J ThijssenMaria T E Hopman
Dec 8, 2017·BioMed Research International·Fei WangXiaoping Chen
Oct 12, 1999·Clinical Physiology·A Pavy-Le TraonC Gharib

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