PMID: 4899455Nov 1, 1969Paper

Changes in leucocyte migration after renal transplantation

British Medical Journal
M G SmithR Williams

Abstract

The leucocyte migration test, an in-vitro measure of cellular immunity, has been used to follow the changes in cell-mediated hypersensitivity to kidney and histocompatibility antigens in three patients after renal transplantation.Inhibition of leucocyte migration, indicating strong sensitization to the antigens used, occurred in each patient, starting five to seven days after transplantation. Satisfactory renal function had not been established in any of the patients at this time. In one case inhibition of leucocyte migration persisted almost continuously until the 24th day and was associated with poor renal function proved histologically to be due to rejection. Treatment with increased dosage of prednisone was associated with a rapid reversion to normal of the migration index and improvement in renal function. Later, inhibition of migration occurred again, and shortly afterwards the graft ceased to function. In the other two cases the migration index became normal without alteration in immunosuppressive therapy and a satisfactory diuresis followed. It is suggested that this simple test should prove useful in the specific diagnosis of rejection and in control of immunosuppressive therapy.

References

May 3, 1969·Lancet·G D ChisholmR Shackman
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Citations

Nov 8, 1979·The New England Journal of Medicine·R D Guttmann
Jun 1, 1976·Scandinavian Journal of Immunology·G BendixenM Søborg
Jul 31, 1971·British Medical Journal·A MunroC S Ogg
Aug 26, 1972·British Medical Journal·M BewickL Manuel
Dec 2, 1972·British Medical Journal·J D BriggsP R Bell
Sep 1, 1971·Journal of Clinical Pathology·K FederlinD C Dumonde
Dec 1, 1972·The British Journal of Venereal Diseases·K W Fulford, J Brostoff
Apr 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P A WaldenP Vernon
Sep 1, 1975·Scandinavian Journal of Immunology·G BendixenJ H Thaysen
May 1, 1971·The Australian and New Zealand Journal of Surgery·P S Hunt
Mar 10, 1976·Archives of Dermatological Research·G Lischka
Oct 1, 1970·Acta Medica Scandinavica·E WeekeG Bendixen
Mar 15, 1972·International Journal of Cancer. Journal International Du Cancer·A SegallF Lacour

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