Changes in leukotrienes and prostaglandins in the liver tissue of rats in the experimental massive hepatic cell necrosis model

Prostaglandins, Leukotrienes, and Essential Fatty Acids
N KawadaS Morisawa

Abstract

When heat-killed Propionibacterium acnes is intravenously injected into rats followed by an intravenous injection of a small amount of Gram-negative lipopolysaccharide (LPS) 7 days later, massive hepatic cell necrosis is induced and most of the rats die within 24 hours of LPS injection. Using this experimental model, we studied the changes in the levels of leukotrienes (LTs) and prostaglandins (PGs) in the liver tissue and bile of rats with experimentally-induced massive hepatic cell necrosis. Both the levels of LTs and PGs in the liver tissue and LTs in the bile increased before the microscopic appearance of hepatic cell necrosis. These results suggest that arachidonic acid metabolites may play an important role in the induction of liver cell injury.

References

Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y MizoguchiS Morisawa
Jun 15, 1983·Biochemical and Biophysical Research Communications·M Rola-PleszczynskiP Sirois

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Citations

Sep 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M NabeshimaT Inubushi
Jan 1, 1994·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·X J Meng, J L Wang
Jan 1, 1993·Pharmacology & Therapeutics·J Quiroga, J Prieto
Oct 16, 2015·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Mustafa İçerCahfer Guloglu
Dec 2, 2008·Prostaglandins & Other Lipid Mediators·Magdalena CuciureanuMihai Nechifor
Oct 15, 1998·Journal of Drug Targeting·B N MelgertD K Meijer
Aug 19, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Aya NishiokadaMakoto Usami
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KawadaS Yamamoto
May 1, 1995·São Paulo Medical Journal = Revista Paulista De Medicina·O Miguel ParraW Abrão Saad
Mar 1, 1993·Gastroenterologia Japonica·Y MizoguchiK Kobayashi
Nov 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N KawadaS Morisawa

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