Abstract
Cardiovascular disease is a leading cause of long-term mortality after liver transplantation (LT). Life long immunosuppression harbors the risk of metabolic alterations. We aimed to analyze the impact of calcineurin (CNI)-only containing regimen (group A) compared to mTOR-containing regimen (group B) on lipid and carbohydrate metabolism. 92 adult patients after LT, University of Mainz (group A-78 patients, group B-14 patients; 65 M/27 F; mean age 59+/-10.2years; mean time from LT 5.8+/-5years). Clinical data, comorbidities, and medication were assessed. Fasting lipid profile including small dense LDLs (sdLDL) and oral glucose tolerance tests were performed. Group B had significantly higher levels of total cholesterol (TC), LDL-cholesterol (LDL-C), triglycerides (TG) and sdLDL, with persistence of higher TC, TG, sdLDLs (mg/dl) after exclusion of patients under lipid lowering medication. Concentrations above the upper limits of normal were found: for LDL-C in 9% of group A/35.7% of group B (p=0.016); for TG: in 32.1% of group A/92.9% in group B (p=0.0001). A positive correlation between time since LT (years) and sdLDL (mg/dl) was found in group B (p=0.018). In patients without previously known diabetes, NODAT and impaired glucose...Continue Reading
References
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Jan 7, 1997·Circulation·B LamarcheJ P Després
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D O TaylorP VanVeldhuisen
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina BerenguerJoaquín Berenguer
Apr 1, 2003·Circulation·Juha VakkilainenUNKNOWN DAIS Group
Feb 19, 2004·Nutrition Reviews·Lais U Monzillo, Osama Hamdy
Jun 4, 2004·Journal of Lipid Research·H C GeissK G Parhofer
Apr 21, 2005·Kidney International·Arja SiirtolaMatti K Salo
Sep 19, 2006·Transplantation Proceedings·S BadiouG Mourad
Jul 25, 2007·Clinical Transplantation·Gero TenderichReiner Koerfer
Nov 6, 2007·International Urology and Nephrology·Despina N PerreaAlkiviadis Kostakis
May 23, 2009·Transplantation Proceedings·G SpagnolettiM Castagneto
May 21, 2011·Pediatric Diabetes·A ProkaiA J Szabo
May 28, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kathleen ClaesHenrik Ekberg
Apr 25, 2012·Diabetologia·S E InzucchiD R Matthews
Oct 19, 2012·Journal of Atherosclerosis and Thrombosis·Hidenori AraiYoshihiro Miyamato
Nov 20, 2012·Molecular and Cellular Endocrinology·Maria J PereiraJan W Eriksson
Jan 3, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael R LuceyLewis W Teperman
Jun 5, 2014·American Journal of Therapeutics·Hoang M LaiWilbert S Aronow
Sep 18, 2014·Transplantation Reviews·Hallvard HoldaasFaouzi Saliba
Mar 13, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ravi ChhatralaM Shadab Siddiqui
Citations
Apr 7, 2016·International Journal of Molecular Sciences·Stefano Gitto, Erica Villa
Oct 20, 2018·Transplantation·Giacomo GermaniKymberly D Watt
Jan 24, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mohammad Bilal SiddiquiMohammad Shadab Siddiqui
Oct 15, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas G Cotter, Michael Charlton
Nov 3, 2016·Current Opinion in Lipidology·Maaike Kockx, Leonard Kritharides
Nov 12, 2016·World Journal of Gastroenterology : WJG·Giuseppina PisanoSilvia Fargion
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Stefano GittoPatrizia Burra
Mar 15, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lee S NguyenJoe-Elie Salem
Dec 15, 2019·Nutrients·Barbara LattanziManuela Merli
Jan 15, 2021·Scientific Reports·Jungchan ParkGaab Soo Kim