Changes in lipid profiles of liver microsomes of rats following intratracheal administration of DDT or endosulfan

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
S NarayanU K Misra

Abstract

The effect of intratracheal administration of DDT (5 mg/100 g body weight) or endosulfan (1 mg/100 g body weight) to rats for three consecutive days, has been studied on liver lipid metabolism. The administration of DDT but not endosulfan significantly increased the liver weight and the microsomal protein contents. Both DDT and endosulfan treatments significantly increased the contents of microsomal phosphatidylcholine (PC), total-free- and esterified cholesterol. The distribution of unsaturated fatty acids of microsomal PC and PE was increased by DDT treatment. The intratracheal administration of DDT caused fatty infiltration of liver which was probably due to increased synthesis of triglycerides (TG). This is supported by the increased incorporation of radioactive palmitate-1-14C into microsomal TG. However, the increased incorporation of palmitate-1-14C into microsomal PC and phosphatidylethanolamine (PE) after the DDT treatment, was due to the increased transacylation reaction supported by the decreased activity of microsomal phospholipase A. The intratracheal administration of endosulfan did not have pronounced effect on liver fatty infiltration, or transacylation reaction in microsomal PC and PE. However, the results have...Continue Reading

Citations

Dec 12, 2012·Environmental Health Perspectives·Michele A La MerrillRobert Barouki
Feb 23, 2008·Journal of Hazardous Materials·Ayhan Demirbas
Feb 27, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Marilyn H Silva, Derek Gammon
Feb 23, 2013·Journal of Toxicology·Cécile CanletLaurence Gamet-Payrastre
Oct 1, 2015·Environmental Health : a Global Access Science Source·Panu RantakokkoJussi Pihlajamäki

Related Concepts

Epicholesterol
DDT (Insecticide)
Thiotox
Saturated Fat
Intubation, Intratracheal
Lipids
Microsomes, Liver
Phosphatidylcholines
Phosphatidylethanolamines
Phospholipases A

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