Changes in liver stiffness and steatosis among patients with hepatitis C virus infection who received direct-acting antiviral therapy and achieved sustained virological response

European Journal of Gastroenterology & Hepatology
Natsuko KobayashiShuhei Nishiguchi

Abstract

Whether direct-acting antiviral (DAA) therapy can reduce liver fibrosis and steatosis in patients with chronic hepatitis C virus (HCV) infection remains unclear. We evaluated sequential changes in liver stiffness and steatosis using transient elastography (TE) and the TE-based controlled attenuation parameter (CAP) in patients with HCV who received DAA therapy. A total of 57 patients with HCV who received DAA therapy and achieved sustained virological response (SVR) were analyzed. Liver stiffness as evaluated with TE, steatosis as evaluated with CAP, and laboratory data were assessed before treatment (baseline), at end of treatment (EOT), 24 weeks after EOT (SVR24), and 48 weeks after EOT (SVR48). Alanine aminotransferase levels, corresponding to the presence of necroinflammatory activity, significantly decreased overall, with significant differences between baseline and EOT, EOT, and SVR24, and baseline and SVR48. However, alanine aminotransferase levels showed no significant changes between SVR24 and SVR48. Median (interquartile range) liver stiffness values at baseline, EOT, SVR24, and SVR48 were 8.3 (5.0-14.8), 7.4 (4.6-14.7), 5.3 (4.1-11.8), and 5.4 (4.0-13.4) kPa, respectively (baseline vs. EOT, P=0.044; EOT vs. SVR24, P=...Continue Reading

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Citations

Mar 1, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheng-Hung ChenCheng-Yuan Peng
Mar 12, 2019·Expert Review of Anti-infective Therapy·Lai Wei, Yi-Hsiang Huang
Nov 7, 2019·European Journal of Gastroenterology & Hepatology·Yoshihiko TachiYoshiaki Katano
Jun 20, 2020·World Journal of Gastroenterology : WJG·Shereen A SalehGhada A Mohamed
Jun 27, 2020·World Journal of Gastroenterology : WJG·Tea L LaursenHenning Grønbæk
Nov 21, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Annalisa CespiatiAnna Ludovica Fracanzani
Mar 13, 2021·International Journal of Clinical Practice·Anahita SadeghiShahin Merat
Apr 4, 2021·Journal of Clinical Medicine·Po-Ke HsuWei-Wen Su
Jun 18, 2021·Frontiers in Medicine·Sergio EstefanMarcia Helena S Costa

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