Changes in liver stiffness during the course of acute hepatitis A

The Korean Journal of Hepatology
Yeon Seok SeoHo Sang Ryu

Abstract

In some patients with chronic hepatitis, liver stiffness (LS) findings do not reflect fibrosis stage. This study was performed to evaluate whether acute liver inflammation could influence LS findings. Patients with acute hepatitis A admitted to our hospital were included. Hepatitis was classified on admission using serum ALT and bilirubin levels as inflammation phase, jaundice phase, or recovery phase. Patients who admitted during the recovery phase (whose ALT and bilirubin levels fell continuously during hospitalization) and therefore, their peak-ALT and peak bilirubin levels could not be determined were exduded. Enrolled patients underwent FibroScan during hospitalization and after discharge. Seventy-six patients with acute hepatitis A were enrolled (median age, 29 years; 46 men and 30 women). Among them, 33 (43.4%) and 43 (56.6%) patients were admitted during the inflammation phase and jaundice phase, respectively. For patients admitted during the inflammation phase, mean (+/-SD) time from symptom-onset day to maximum ALT level was 7 (+/-3) days. For all patients, mean time from symptom-onset to maximum bilirubin level was 11 (+/-4) days. Mean LS during admission was 8.9 (+/-Pa (median, 8.4 kPa). LS was significantly correla...Continue Reading

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Citations

Aug 30, 2011·Journal of Gastroenterology and Hepatology·Hui-Ying RaoLai Wei
Mar 26, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masao HarataKentaro Yoshioka
Jul 29, 2011·European Journal of Clinical Investigation·Kristoffer LindvigPeer B Christensen
Dec 29, 2009·The Korean Journal of Hepatology·Yeon Seok Seo
Dec 29, 2009·The Korean Journal of Hepatology·Da Mi LeeJin Mo Yang
Dec 29, 2009·The Korean Journal of Hepatology·Seung Young KimJai Hyun Choi
Jan 12, 2010·Scandinavian Journal of Gastroenterology·Yeon Seok SeoSoon Ho Um
Jul 21, 2021·PLoS Neglected Tropical Diseases·Yuri Costa Sarno NevesMaria Cristina Chammas

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