PMID: 3930880Oct 1, 1985Paper

Changes in lung vascular permeability after heart-lung transplantation

The Journal of Surgical Research
M C ManciniR L Hardesty


We have employed multiple indicator dilution techniques (MID) in six patients after heart-lung transplantation to assess changes in the lung vascular permeability-surface area product for urea (PS). Serial PS values for the patients when normalized to the predicted total lung capacity (TLC) in liters, ranged between 1.04 and 6.27 ml/sec/TLC (patient 1), 0 and 2.76 ml/sec/TLC (patient 2), 0.59 and 2.88 ml/sec/TLC (patient 3), 0.13 and 1.23 ml/sec/TLC (patient 4). The elevated values for PS in patient 1 exceed the lethal range described by K.L. Brigham et al. (J. Clin. Invest. 72:339, 1983) for severe ARDS. This strongly suggests a severely increased lung microvascular permeability in this patient possibly secondary to rejection as indicated by endomyocardial biopsy. PS values for surviving patients 2-6 fell well below the corresponding lethal value for ARDS patients. We conclude that PS urea derived from MID provides an indicator of the status of lung microvascular integrity in heart-lung transplant recipients.


Jun 1, 1978·Circulation Research·K L BrighamM Stahlman
Oct 1, 1974·The Journal of Clinical Investigation·K L BrighamN C Staub
Jan 1, 1984·Transplantation·S W JamiesonC P Bieber
Mar 11, 1982·The New England Journal of Medicine·B A ReitzN E Shumway

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Jan 1, 1987·The American Journal of the Medical Sciences·B G Firth
Apr 15, 1999·Clinical Transplantation·A H TirokeA Haverich
Jan 1, 1992·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M C Mancini
Mar 10, 2001·The Annals of Thoracic Surgery·R P Scott

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