PMID: 8941973Sep 1, 1996Paper

Changes in lymphocyte subsets with age in perinatal cats: late gestation through eight weeks

Veterinary Immunology and Immunopathology
R K SellonW A Tompkins

Abstract

The age-related changes in numbers and proportions of peripheral blood lymphocyte subsets (pan-T, CD4, CD8, Ig, and null) were evaluated by two-color flow cytometry in 16 feline fetuses (56-58 days gestational age) and 21 kittens from birth through 8 weeks of age. Populations of pan-T+, CD4+, and CD8+ cells increased in total numbers as a function of increases in total lymphocyte numbers while proportions of these subsets remained relatively static. In contrast, both the total number and proportion of Ig+ cells increased from birth to 4 weeks of age, after which there were essentially no changes. Null (pan-T-, Ig-) cells were highest during late gestation and declined steadily thereafter to become a minimal component of the peripheral lymphocyte subsets. Compared with normal adult values, CD4/CD8 ratios were high throughout the 8 week study period. These results illustrate that the neonatal cat blood lymphocyte profile undergoes maturational changes and emphasize the importance of evaluating age-matched controls in studies of conditions that may alter feline lymphocyte subsets.

References

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Nov 1, 1990·Immunology Today·J Westermann, R Pabst
Jan 1, 1995·AIDS Research and Human Retroviruses·L L O'NeilE A Hoover
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Citations

Sep 15, 2001·Veterinary Immunology and Immunopathology·M FaldynaM Toman
Feb 9, 2000·The Journal of Small Animal Practice·M J Day
Jan 25, 2012·Journal of Veterinary Internal Medicine·K J BaxterM B Tompkins
Jun 15, 2007·Journal of Comparative Pathology·M J Day
Nov 28, 2006·Developmental and Comparative Immunology·Edita JeklovaMartin Faldyna
Mar 1, 2005·Veterinary Immunology and Immunopathology·M FaldynaM Toman
Dec 23, 2011·Vaccine·Douglas C Hodgins, Patricia E Shewen

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