Changes in markers of liver function in relation to changes in perfluoroalkyl substances - A longitudinal study

Environment International
Samira SalihovicP Monica Lind

Abstract

While it is known that perfluoroalkyl substances (PFASs) induce liver toxicity in experimental studies, the evidence of an association in humans is inconsistent. The main aim of the present study was to examine the association of PFAS concentrations and markers of liver function using panel data. We investigated 1002 individuals from Sweden (50% women) at ages 70, 75 and 80 in 2001-2014. Eight PFASs were measured in plasma using isotope dilution ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). Bilirubin and hepatic enzymes alanine aminotransferase (ALT), alkaline phosphatase (ALP), and γ-glutamyltransferase (GGT) were determined in serum using an immunoassay methodology. Mixed-effects linear regression models were used to examine the relationship between the changes in markers of liver function and changes in PFAS levels. The changes in majority of PFAS concentrations were positively associated with the changes in activity of ALT, ALP, and GGT and inversely associated with the changes in circulating bilirubin after adjustment for gender and the time-updated covariates LDL- and HDL-cholesterol, serum triglycerides, BMI, statin use, smoking, fasting glucose levels and correction for multiple testing....Continue Reading

Citations

Oct 1, 2020·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel)Tanja Schwerdtle
Nov 30, 2018·Journal of Exposure Science & Environmental Epidemiology·Judith M GraberClifford P Weisel
Aug 2, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nikos StratakisLida Chatzi
Sep 30, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marisa PfohlAngela L Slitt
Nov 5, 2020·International Journal of Environmental Research and Public Health·Marco BonatoGianfranco Santovito
Jan 24, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marisa PfohlAngela L Slitt
Apr 16, 2021·Critical Reviews in Toxicology·Styliani FragkiMirjam Luijten
Jul 15, 2021·Environmental Science & Technology·Dimitri Panagopoulos AbrahamssonTracey J Woodruff

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