Changes in maternal serum transforming growth factor beta-1 during pregnancy: a cross-sectional study

BioMed Research International
Mandeep SinghJustin C Konje

Abstract

Changes in circulating levels of maternal serum transforming growth factor beta-1 (TGF-β1), collected from 98 women (AGA) at different gestational ages (10-38 weeks) were measured and comparisons were made between levels in pregnant and nonpregnant controls and also between 10 women with small-for-gestational age (SGA) and 7 with appropriate-for-gestational age (AGA) fetuses. Maternal serum TGF-β1 levels at all stages of pregnancy were higher than those in normal healthy nonpregnant adults. The mean TGF-β1 levels in SGA pregnancies at 34-week gestation (32.5 + 3.2 ng/mL) were significantly less than those in AGA pregnancies (39.2 + 9.8 ng/mL) while at 38-week gestation, the levels were similar in the two groups (36.04 + 4.3 versus 36.7 + 7.0 ng/mL). This differential change in TGF-β1 levels is probably an important modulating factor in the aetiopathogenesis of abnormal intrauterine fetal growth.

References

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Citations

Mar 3, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·N PerioloE Baumeister
Jul 14, 2020·Frontiers in Immunology·Juliette KropMichael Eikmans
Jun 26, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sean R HolmCatherine A Thornton

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Methods Mentioned

BETA
SGA
biopsies

Software Mentioned

GraphPad Prism

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