Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning

Proceedings of the National Academy of Sciences of the United States of America
Desheng WangBernard G Schreurs

Abstract

Previous studies have shown changes in membrane properties of neurons in rat deep cerebellar nuclei (DCN) as a function of development, but due to technical difficulties in obtaining viable DCN slices from adult animals, it remains unclear whether there are learning-related alterations in the membrane properties of DCN neurons in adult rats. This study was designed to record from identified DCN cells in cerebellar slices from postnatal day 25-26 (P25-26) rats that had a relatively mature sensory nervous system and were able to acquire learning as a result of tone-shock eyeblink conditioning (EBC) and to document resulting changes in electrophysiological properties. After electromyographic electrode implantation at P21 and inoculation with a fluorescent pseudorabies virus (PRV-152) at P22-23, rats received either four sessions of paired delay EBC or unpaired stimulus presentations with a tone conditioned stimulus and a shock unconditioned stimulus or sat in the training chamber without stimulus presentations. Compared with rats given unpaired stimuli or no stimulus presentations, rats given paired EBC showed an increase in conditioned responses across sessions. Whole-cell recordings of both fluorescent and nonfluorescent DCN pro...Continue Reading

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Citations

Sep 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Cathrin B CantoChris I De Zeeuw
May 6, 2020·The FEBS Journal·Gen OhtsukiAkitoshi Ozaki
Mar 22, 2019·Frontiers in Cellular Neuroscience·Letizia MoscatoEgidio D'Angelo
Mar 26, 2019·Journal of Alzheimer's Disease : JAD·Desheng Wang
May 18, 2020·Neuroscience and Biobehavioral Reviews·Derick H Lindquist
Dec 8, 2020·Neurobiology of Learning and Memory·Deidre E O'DellDesheng Wang
Jan 26, 2021·IScience·Yuxuan ZhaoGuang Qiao

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