Abstract
Previous studies have investigated the impact of venesection upon different metabolic indices in patients with various conditions (e.g., type 2 diabetes and iron overload). We aimed to investigate the changes on different metabolic indices including glycemic, iron, lipids and inflammatory markers at different time points after blood donation in male subjects with normal glucose tolerance. 42 male subjects were recruited to the study. Glucose tolerance was assessed by oral glucose tolerance test before (visit A) and after the blood donation (1day, visit B; 1week, visit C; 3weeks, visit D; and 3months, visit E). Fasting glucose, HbA1c, insulin, lipids, uric acid, C-reactive protein, iron stores and insulin resistance (HOMA-IR, ISI-gly) indices were measured. A repeated measures ANOVA was used for comparisons of quantitative variables between different visits. All subjects had normal glucose tolerance according to WHO criteria. Fasting glucose, insulin and HOMA-IR were significantly higher (~2%, p<0.05; ~21%, p<0.01; and ~11%, p<0.05 respectively) at visit B following donation. At visit D, the mean±SE for HbA1c (5.28±0.06%) was significantly lower with a difference in percentage of ~-3% and p<0.05 compared to visit A (5.44±0.06%)....Continue Reading
References
Dec 1, 1989·Resuscitation·E CasigliaA C Pessina
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·C G Fraser, E K Harris
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Aug 1, 1993·The Journal of Clinical Endocrinology and Metabolism·K DmochowskiB Zinman
Mar 15, 1997·BMJ : British Medical Journal·T P TuomainenJ T Salonen
May 1, 1998·Molecular Genetics and Metabolism·F BelfioreG Volpicelli
Sep 16, 1998·American Journal of Epidemiology·J T SalonenK Nyyssönen
Oct 1, 1998·Biochemical and Biophysical Research Communications·M QianJ W Eaton
Dec 5, 1998·Diabetes Care·D M Gorson
Jan 4, 2001·Circulation·A AscherioM J Stampfer
May 31, 2001·Diabetologia·M BertelsenM J Carrier
Mar 28, 2002·Diabetes·José Manuel Fernández-RealWifredo Ricart
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·A CagnacciA Volpe
Jun 25, 2005·Clinical Chemistry·José Manuel Fernández-RealWifredo Ricart
Jun 28, 2007·Annals of Clinical Biochemistry·Anwar BoraiGordon A A Ferns
Jul 17, 2007·Diabetes Care·Haoyi ZhengStuart D Katz
Nov 25, 2011·BMC Medical Research Methodology·Anwar BoraiGordon Ferns
Citations
May 6, 2016·Annual Review of Nutrition·Marie Balslev BackeThomas Mandrup-Poulsen
Mar 16, 2019·Heart·Karlijn PefferFemke Atsma
Jan 25, 2017·PloS One·Angelique DijkstraMichel J Vos
Mar 24, 2017·Journal of Diabetes Research·James C Barton, Ronald T Acton
Jan 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Andrés E Ortiz-FloresManuel Luque-Ramírez