Changes in metabolic indices in response to whole blood donation in male subjects with normal glucose tolerance

Clinical Biochemistry
Anwar BoraiGordon Ferns

Abstract

Previous studies have investigated the impact of venesection upon different metabolic indices in patients with various conditions (e.g., type 2 diabetes and iron overload). We aimed to investigate the changes on different metabolic indices including glycemic, iron, lipids and inflammatory markers at different time points after blood donation in male subjects with normal glucose tolerance. 42 male subjects were recruited to the study. Glucose tolerance was assessed by oral glucose tolerance test before (visit A) and after the blood donation (1day, visit B; 1week, visit C; 3weeks, visit D; and 3months, visit E). Fasting glucose, HbA1c, insulin, lipids, uric acid, C-reactive protein, iron stores and insulin resistance (HOMA-IR, ISI-gly) indices were measured. A repeated measures ANOVA was used for comparisons of quantitative variables between different visits. All subjects had normal glucose tolerance according to WHO criteria. Fasting glucose, insulin and HOMA-IR were significantly higher (~2%, p<0.05; ~21%, p<0.01; and ~11%, p<0.05 respectively) at visit B following donation. At visit D, the mean±SE for HbA1c (5.28±0.06%) was significantly lower with a difference in percentage of ~-3% and p<0.05 compared to visit A (5.44±0.06%)....Continue Reading

References

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Nov 25, 2011·BMC Medical Research Methodology·Anwar BoraiGordon Ferns

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Citations

May 6, 2016·Annual Review of Nutrition·Marie Balslev BackeThomas Mandrup-Poulsen
Jan 25, 2017·PloS One·Angelique DijkstraMichel J Vos
Mar 24, 2017·Journal of Diabetes Research·James C Barton, Ronald T Acton
Jan 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Andrés E Ortiz-FloresManuel Luque-Ramírez

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