Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease

Microbiome
Sahil KhannaPurna Kashyap

Abstract

Gut microbiota play a key role in maintaining homeostasis in the human gut. Alterations in the gut microbial ecosystem predispose to Clostridium difficile infection (CDI) and gut inflammatory disorders such as inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) from a healthy donor can restore gut microbial diversity and pathogen colonization resistance; consequently, it is now being investigated for its ability to improve inflammatory gut conditions such as IBD. In this study, we investigated changes in gut microbiota following FMT in 38 patients with CDI with or without underlying IBD. There was a significant change in gut microbial composition towards the donor microbiota and an overall increase in microbial diversity consistent with previous studies after FMT. FMT was successful in treating CDI using a diverse set of donors, and varying degrees of donor stool engraftment suggesting that donor type and degree of engraftment are not drivers of a successful FMT treatment of CDI. However, patients with underlying IBD experienced an increased number of CDI relapses (during a 24-month follow-up) and a decreased growth of new taxa, as compared to the subjects without IBD. Moreover, the need for IBD therapy did...Continue Reading

References

Dec 8, 2005·Applied and Environmental Microbiology·Catherine Lozupone, Rob Knight
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jul 19, 2011·Nature Methods·Dan KnightsScott T Kelley
Oct 17, 2012·Bioinformatics·Evguenia KopylovaHélène Touzet
Nov 28, 2013·GigaScience·Yoshiki Vázquez-BaezaRob Knight
Jan 7, 2014·Mayo Clinic Proceedings·Sahil Khanna, Pritish K Tosh
Mar 4, 2014·Therapeutic Advances in Gastroenterology·Sahil Khanna, Darrell S Pardi
Mar 19, 2014·Cell Host & Microbe·Dirk GeversRamnik J Xavier
Jan 7, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Daniel P Faith
Nov 14, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert OrensteinUNKNOWN PUNCH CD Investigators
Feb 26, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alexander KhorutsMichael J Sadowsky
Feb 26, 2016·The Journal of Infectious Diseases·Sahil KhannaElizabeth L Hohmann
Feb 14, 2017·Nature Microbiology·Jonas HalfvarsonJanet K Jansson

❮ Previous
Next ❯

Citations

Feb 21, 2018·Journal of Veterinary Internal Medicine·Giorgio Q PereiraMarcio C Costa
Apr 19, 2018·Human Molecular Genetics·Lianmin ChenCisca Wijmenga
Jun 26, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Sonia Bouri, Ailsa Hart
Aug 10, 2018·PLoS Computational Biology·Patrick H BradleyKatherine S Pollard
Dec 13, 2018·Journal of Pediatric Gastroenterology and Nutrition·Zev H DavidovicsUNKNOWN FMT Special Interest Group of the North American Society of Pediatric Gastroenterology Hepatology, Nutrition, the European S
Feb 20, 2019·Experimental Biology and Medicine·Se Jin SongRob Knight
May 11, 2018·Immunopharmacology and Immunotoxicology·Christian L HvasJørgen Agnholt
Jun 21, 2019·The Journal of International Medical Research·Sabreen Abdul Rahman JagessarFaming Zhang
Oct 27, 2017·Clinical Pharmacology and Therapeutics·Sahil Khanna
Aug 19, 2020·Journal of Crohn's & Colitis·Scott W Olesen, Ylaine Gerardin
Oct 6, 2019·Nature Communications·Thomas A HamiltonDavid R Edgell
Aug 26, 2017·Digestive Diseases and Sciences·Colleen R Kelly, Jessica R Allegretti
Feb 6, 2019·Frontiers in Cellular and Infection Microbiology·Brooke C WilsonJustin M O'Sullivan
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Hari Ram, Syed G Dastager
May 21, 2019·American Journal of Lifestyle Medicine·Dexter Shurney
May 31, 2019·Journal of Immunology Research·Wenjie ZengMingyi Zhao
Jun 27, 2019·Transfusion·Simon Mark Dahl JørgensenChristian Erikstrup
Apr 15, 2019·Obesity Surgery·Josianne C H B M LuijtenMisha D P Luyer
Aug 28, 2020·Nature Reviews. Gastroenterology & Hepatology·Alexander KhorutsMichael J Sadowsky
Aug 22, 2020·World Journal of Gastroenterology : WJG·Yezaz A GhouriBo Shen
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Graham J BrittonJeremiah J Faith
Sep 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Srishti SahaSahil Khanna
Nov 17, 2020·Gastroenterology·Meng PuPurna C Kashyap
Feb 1, 2020·Journal of Hepatology·Jasmohan S Bajaj, Alexander Khoruts
Jul 15, 2018·Current Opinion in Microbiology·James C StegenJanet K Jansson
Apr 8, 2021·British Journal of Cancer·Maximilian BoeschMartin H Brutsche
Jun 15, 2021·Frontiers in Aging Neuroscience·Shaochang WuZongxin Ling
Oct 21, 2021·Journal of Gastroenterology and Hepatology·Joseph J Y Sung, Sunny H Wong

❮ Previous
Next ❯

Datasets Mentioned

BETA
ERP021216

Software Mentioned

Quantitative Insights Into Microbial Ecology ( QIIME )
ANCOM
JMP
SourceTracker
Seaborn
PERMANOVA
Emperor
UniFrac
SortMeRNA
SciPy

Related Concepts

Related Feeds

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.